LongevityMap Gene

Gene details

HGNC symbol
ADCY5 
Aliases
AC5; FDFM 
Common name
adenylate cyclase 5 
Description
This gene encodes a member of the membrane-bound adenylyl cyclase enzymes. Adenylyl cyclases mediate G protein-coupled receptor signaling through the synthesis of the second messenger cAMP. Activity of the encoded protein is stimulated by the Gs alpha subunit of G protein-coupled receptors and is inhibited by protein kinase A, calcium and Gi alpha subunits. Single nucleotide polymorphisms in this gene may be associated with low birth weight and type 2 diabetes. Alternatively spliced transcript variants that encode different isoforms have been observed for this gene. [provided by RefSeq, Dec 2010]
Cytogenetic Location
3q21.1
UCSC Genome Browser
View 3q21.1 on the UCSC genome browser
OMIM
600293
Ensembl
ENSG00000173175
UniProt/Swiss-Prot
ADCY5_HUMAN
Entrez Gene
111
UniGene
593292
1000 Genomes
1000 Genomes

Homologs in model organisms

Danio rerio
adcy5
Drosophila melanogaster
CG43373
Mus musculus
Adcy5
Rattus norvegicus
Adcy5

In other databases

GenAge model organism genes
  • A homolog of this gene for Mus musculus is present as Adcy5
GenAge human genes
  • This gene is present as ADCY5
GenDR gene manipulations
  • A homolog of this gene for Mus musculus is present as Adcy5

Studies (1)

Significant/Non-significant: 0/1

Longevity Association
Non-significant
Population
Chinese
Study Design
A 10-year follow-up study of the Chinese longitudinal healthy longevity survey was performed consisting of 963 long-lived and 1028 geography-matched young individuals. Sixteen SNPs from ADRB1, ADRB2, ADCY5, ADCY6, and MAPK1 were selected and genotyped.
Conclusions
None of the tested single nucleotide polymorphisms, excepting rs1042718 (C/A) and rs1042719 (G/C), showed a significant association with the longevity phenotype
Indentifier
rs2877709
Reference