LongevityMap Gene
Gene details
- HGNC symbol
- ADCY5
- Aliases
- AC5; FDFM
- Common name
- adenylate cyclase 5
- Description
- This gene encodes a member of the membrane-bound adenylyl cyclase enzymes. Adenylyl cyclases mediate G protein-coupled receptor signaling through the synthesis of the second messenger cAMP. Activity of the encoded protein is stimulated by the Gs alpha subunit of G protein-coupled receptors and is inhibited by protein kinase A, calcium and Gi alpha subunits. Single nucleotide polymorphisms in this gene may be associated with low birth weight and type 2 diabetes. Alternatively spliced transcript variants that encode different isoforms have been observed for this gene. [provided by RefSeq, Dec 2010]
- Cytogenetic Location
- 3q21.1
- UCSC Genome Browser
- View 3q21.1 on the UCSC genome browser
- OMIM
- 600293
- Ensembl
- ENSG00000173175
- UniProt/Swiss-Prot
- ADCY5_HUMAN
- Entrez Gene
- 111
- UniGene
- 593292
- 1000 Genomes
- 1000 Genomes
Homologs in model organisms
In other databases
- GenAge model organism genes
- A homolog of this gene for Mus musculus is present as Adcy5
- GenAge human genes
- This gene is present as ADCY5
- GenDR gene manipulations
- A homolog of this gene for Mus musculus is present as Adcy5
Studies (1)
Significant/Non-significant: 0/1
- Longevity Association
- Non-significant
- Population
- Chinese
- Study Design
- A 10-year follow-up study of the Chinese longitudinal healthy longevity survey was performed consisting of 963 long-lived and 1028 geography-matched young individuals. Sixteen SNPs from ADRB1, ADRB2, ADCY5, ADCY6, and MAPK1 were selected and genotyped.
- Conclusions
- None of the tested single nucleotide polymorphisms, excepting rs1042718 (C/A) and rs1042719 (G/C), showed a significant association with the longevity phenotype
- Indentifier
- rs2877709
- Reference