Mus musculusGenAge entry for Adcy5 (Mus musculus)

Gene information (ID: 6)

Symbol
Adcy5
Aliases
Ac5; AW121902
Name
adenylate cyclase 5
Organism
Mus musculus (AnAge)
Known functions and activities
Synthesis of cAMP

Potential relevance to longevity and/or ageing

Observations
Knock out mice are resistant to cardiac stress, have an increased median lifespan of 30% and an increased maximal lifespan of 12%. They are also protected from age-related reduced bone density and susceptibility to fractures, and reduced cardiac function.
% change in max lifespan
Maximum lifespan is 12% higher.
% change in avg or median lifespan
Median lifespan is 30% higher.
Lifespan Effect
Increase
Genetic Manipulation
Knockout
Longevity Category
Anti-Longevity
Primary reference

    In other databases

    GenAge human genes
    • A homolog of this gene for Homo sapiens is present as ADCY5
    GenDR gene manipulations
    • This gene is present as Adcy5
    LongevityMap
    • A homolog of this gene for Homo sapiens is present as ADCY5

    Homologs in other organisms

    Danio rerio
    adcy5
    Drosophila melanogaster
    CG43373
    Homo sapiens
    ADCY5
    Rattus norvegicus
    Adcy5

    External links

    Mouse Genome Informatics
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    Ensembl
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    Entrez Gene
    View on Entrez Gene database (224129)
    Homologues
    Search HomoloGene
    UniProt
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    Internet
    Search Google or Search Google Scholar