LongevityMap variant
- Longevity Association
- Non-significant
- Population
- Italian
- Study Design
- T/C, 359 bp and A/G, 303 bp polymorphisms were examined in healthy people 17-85 yr of age (n= 278; mean age, 54.8; 76 males and 202 females) and in healthy people 86-109 yr of age (n= 218; mean age, 98.0; 56 males and 162 females)
- Conclusions
- No significant differences relative to longevity were found, though some differences in genotype combinations with IGF1R were observed
- HGNC symbol
- PIK3CB
- Aliases
- PI3K; PIK3C1; P110BETA; PI3KBETA
- Common name
- phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta
- Description
- This gene encodes an isoform of the catalytic subunit of phosphoinositide 3-kinase (PI3K). These kinases are important in signaling pathways involving receptors on the outer membrane of eukaryotic cells and are named for their catalytic subunit. The encoded protein is the catalytic subunit for PI3Kbeta (PI3KB). PI3KB has been shown to be part of the activation pathway in neutrophils which have bound immune complexes at sites of injury or infection. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2011]
- Other longevity studies of this gene
- 1
- OMIM
- 602925
- Ensembl
- ENSG00000051382
- UniProt/Swiss-Prot
- B4DER4_HUMAN
- Entrez Gene
- 5291
- UniGene
- 239818
- HapMap
- View on HapMap
Homologs in model organisms
- Danio rerio
- pik3cb
- Drosophila melanogaster
- Pi3K92E
- Mus musculus
- Pik3cb
- Rattus norvegicus
- Pik3cb
- Rattus norvegicus
- LOC100910021
- Saccharomyces cerevisiae
- VPS34
- GenAge model organism genes
- A homolog of this gene for Drosophila melanogaster is present as Pi3K92E
- A homolog of this gene for Saccharomyces cerevisiae is present as VPS34
- GenAge human genes
- This gene is present as PIK3CB
Bonafè et al. (2003)
Other variants which are also part of this study
