LongevityMap Gene

Gene details

HGNC symbol: PIK3CB
Aliases: PI3K; PIK3C1; P110BETA; PI3KBETA
Common name: phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta
Description: This gene encodes an isoform of the catalytic subunit of phosphoinositide 3-kinase (PI3K). These kinases are important in signaling pathways involving receptors on the outer membrane of eukaryotic cells and are named for their catalytic subunit. The encoded protein is the catalytic subunit for PI3Kbeta (PI3KB). PI3KB has been shown to be part of the activation pathway in neutrophils which have bound immune complexes at sites of injury or infection. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2011]
Cytogenetic Location: 3q22.3
UCSC Genome Browser: View 3q22.3 on the UCSC genome browser
OMIM: 602925
Ensembl: ENSG00000051382
UniProt/Swiss-Prot: B4DER4_HUMAN
Entrez Gene: 5291
UniGene: 239818
1000 Genomes: 1000 Genomes

Homologs in model organisms

Danio rerio: pik3cb
Drosophila melanogaster: Pi3K92E
Mus musculus: Pik3cb
Rattus norvegicus: Pik3cb
Rattus norvegicus: LOC100910021
Saccharomyces cerevisiae: VPS34

In other databases

GenAge model organism genes

A homolog of this gene for Drosophila melanogaster is present as Pi3K92E
A homolog of this gene for Saccharomyces cerevisiae is present as VPS34

GenAge human genes

This gene is present as PIK3CB

Studies (2)

Significant/Non-significant: 0/2

Study 1

Longevity Association

Non-significant

Population

Study Design

T/C, 359 bp and A/G, 303 bp polymorphisms were examined in healthy people 17-85 yr of age (n= 278; mean age, 54.8; 76 males and 202 females) and in healthy people 86-109 yr of age (n= 218; mean age, 98.0; 56 males and 162 females)

Conclusions

No significant differences relative to longevity were found, though some differences in genotype combinations with IGF1R were observed

Indentifier

Reference

Study 2

Longevity Association

Non-significant

Population

Study Design

2 promoter and 1 intron polymorphisms were examined in 122 semisupercentenarians (older than 105, 107 female, 15 male, mean age 106.8 years) and 122 healthy younger controls (105 female, 17 male, mean age 33.33)

Conclusions

No significant differences relative to longevity were found

Indentifier

Reference