LongevityMap variant
- Longevity Association
- Non-significant
- Population
- Dutch
- Study Design
- The 1-bp guanine deletion/insertion (4G/5G) polymorphism in the promoter region was examined in 648 subjects >85 years old
- Conclusions
- In the cross-sectional analysis, the genotype distributions were similar in elderly and young subjects
- HGNC symbol
- SERPINE1
- Aliases
- PAI; PAI1; PAI-1; PLANH1
- Common name
- serpin family E member 1
- Description
- This gene encodes a member of the serine proteinase inhibitor (serpin) superfamily. This member is the principal inhibitor of tissue plasminogen activator (tPA) and urokinase (uPA), and hence is an inhibitor of fibrinolysis. Defects in this gene are the cause of plasminogen activator inhibitor-1 deficiency (PAI-1 deficiency), and high concentrations of the gene product are associated with thrombophilia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]
- Other longevity studies of this gene
- 6
- OMIM
- 173360
- Ensembl
- ENSG00000106366
- UniProt/Swiss-Prot
- A0A024QYT5_HUMAN
- Entrez Gene
- 5054
- UniGene
- 414795
- HapMap
- View on HapMap
Homologs in model organisms
- Caenorhabditis elegans
- srp-3
- Caenorhabditis elegans
- srp-2
- Caenorhabditis elegans
- srp-1
- Caenorhabditis elegans
- srp-7
- Caenorhabditis elegans
- srp-6
- Caenorhabditis elegans
- srp-8
- Danio rerio
- serpine1
- Drosophila melanogaster
- Spn38F
- Drosophila melanogaster
- Spn28F
- Drosophila melanogaster
- Spn42Dd
- Drosophila melanogaster
- Spn42Da
- Drosophila melanogaster
- Spn28Db
- Drosophila melanogaster
- Spn55B
- Drosophila melanogaster
- Spn42Db
- Drosophila melanogaster
- Spn28Da
- Drosophila melanogaster
- Spn28B
- Drosophila melanogaster
- Spn42Dc
- Drosophila melanogaster
- Spn42De
- Drosophila melanogaster
- nec
- Drosophila melanogaster
- Spn43Aa
- Drosophila melanogaster
- Spn43Ab
- Drosophila melanogaster
- Spn47C
- Mus musculus
- Serpine1
- Rattus norvegicus
- Serpine1
- GenAge model organism genes
- A homolog of this gene for Mus musculus is present as Serpine1
- GenAge human genes
- GenAge microarray genes
- CellAge
Heijmans et al. (1999)
Other variants which are also part of this study