LongevityMap variant

Entry Details

Longevity Association: Non-significant
Population: American (Caucasian)
Study Design: Genotypes for -675 4G/5G were studied in 2224 men and women aged 65 years and older at baseline
Conclusions: 4G/4G genotype appeared to be associated with lower non-cardiovascular mortality in men, but with greater cardiovascular mortality in women

HGNC symbol: SERPINE1
Aliases: PAI; PAI1; PAI-1; PLANH1
Common name: serpin family E member 1
Description: This gene encodes a member of the serine proteinase inhibitor (serpin) superfamily. This member is the principal inhibitor of tissue plasminogen activator (tPA) and urokinase (uPA), and hence is an inhibitor of fibrinolysis. Defects in this gene are the cause of plasminogen activator inhibitor-1 deficiency (PAI-1 deficiency), and high concentrations of the gene product are associated with thrombophilia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]
Other longevity studies of this gene: 6
OMIM: 173360
Ensembl: ENSG00000106366
UniProt/Swiss-Prot: A0A024QYT5_HUMAN
Entrez Gene: 5054
UniGene: 414795
HapMap: View on HapMap

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GenAge human genes

CellAge

Reiner et al. (2005)