LongevityMap variant

Entry Details

Longevity Association: Significant
Population: American (Caucasian)
Study Design: Common polymorphisms in the ADRB2 gene were studied for association with survival and longevity in the Framingham Heart Study Offspring cohort for which data was available for 1565 subjects
Conclusions: The Gln27Glu and Glu27Glu genotypes and the Glu27 allele were associated with shorter lifespans at young-old ages (cut-off = 72 years) and longer lives in oldest-old ages (e.g., cut-off = 83 years) compared to carriers of the Gln27Gln genotype. The Gln(27)Gln genotype was also associated with age-related diseases, such as cancer.

HGNC symbol: ADRB2
Aliases: BAR; B2AR; ADRBR; ADRB2R; BETA2AR
Common name: adrenoceptor beta 2
Description: This gene encodes beta-2-adrenergic receptor which is a member of the G protein-coupled receptor superfamily. This receptor is directly associated with one of its ultimate effectors, the class C L-type calcium channel Ca(V)1.2. This receptor-channel complex also contains a G protein, an adenylyl cyclase, cAMP-dependent kinase, and the counterbalancing phosphatase, PP2A. The assembly of the signaling complex provides a mechanism that ensures specific and rapid signaling by this G protein-coupled receptor. This gene is intronless. Different polymorphic forms, point mutations, and/or downregulation of this gene are associated with nocturnal asthma, obesity and type 2 diabetes. [provided by RefSeq, Jul 2008]
Other longevity studies of this gene: 6
OMIM: 109690
Ensembl: ENSG00000169252
UniProt/Swiss-Prot: ADRB2_HUMAN
Entrez Gene: 154
UniGene: 2551
HapMap: View on HapMap

Kulminski et al. (2010)