LongevityMap Gene

Gene details

HGNC symbol: ADRB2
Aliases: BAR; B2AR; ADRBR; ADRB2R; BETA2AR
Common name: adrenoceptor beta 2
Description: This gene encodes beta-2-adrenergic receptor which is a member of the G protein-coupled receptor superfamily. This receptor is directly associated with one of its ultimate effectors, the class C L-type calcium channel Ca(V)1.2. This receptor-channel complex also contains a G protein, an adenylyl cyclase, cAMP-dependent kinase, and the counterbalancing phosphatase, PP2A. The assembly of the signaling complex provides a mechanism that ensures specific and rapid signaling by this G protein-coupled receptor. This gene is intronless. Different polymorphic forms, point mutations, and/or downregulation of this gene are associated with nocturnal asthma, obesity and type 2 diabetes. [provided by RefSeq, Jul 2008]
Cytogenetic Location: 5q32
UCSC Genome Browser: View 5q32 on the UCSC genome browser
OMIM: 109690
Ensembl: ENSG00000169252
UniProt/Swiss-Prot: ADRB2_HUMAN
Entrez Gene: 154
UniGene: 2551
1000 Genomes: 1000 Genomes

Homologs in model organisms

Caenorhabditis elegans: ser-3
Caenorhabditis elegans: ser-6
Caenorhabditis elegans: ser-5
Danio rerio: adrb2b
Danio rerio: adrb2a
Drosophila melanogaster: Oamb
Mus musculus: Adrb2
Rattus norvegicus: Adrb2

Studies (4)

Significant/Non-significant: 2/2

Study 1

Longevity Association: Non-significant
Population: American (Caucasian)
Study Design: Common polymorphisms in the ADRB2 gene were studied for association with survival and longevity in the Framingham Heart Study Offspring cohort for which data was available for 1565 subjects
Conclusions: No significant associations with longevity were reported for the Arg(16)Gly polymorphism
Indentifier

Study 2

Longevity Association: Significant
Population: Chinese
Study Design: A 10-year follow-up study of the Chinese longitudinal healthy longevity survey was performed consisting of 963 long-lived and 1028 geography-matched young individuals. Sixteen SNPs from ADRB1, ADRB2, ADCY5, ADCY6, and MAPK1 were selected and genotyped.
Conclusions: Two SNPs, rs1042718 (C/A) and rs1042719 (G/C), of ADRB2 in linkage disequilibrium were found to be associated with enhanced longevity in men in two geographically isolated populations. Men with haplotype A-C showed an increased probability to become centenarians , in contrast to those with haplotype C-G.
Indentifier

Study 3

Longevity Association: Non-significant
Population: Chinese
Study Design: A 10-year follow-up study of the Chinese longitudinal healthy longevity survey was performed consisting of 963 long-lived and 1028 geography-matched young individuals. Sixteen SNPs from ADRB1, ADRB2, ADCY5, ADCY6, and MAPK1 were selected and genotyped.
Conclusions: None of the tested single nucleotide polymorphisms, excepting rs1042718 (C/A) and rs1042719 (G/C), showed a significant association with the longevity phenotype
Indentifier

Study 4

Longevity Association: Significant
Population: American (Caucasian)
Study Design: Common polymorphisms in the ADRB2 gene were studied for association with survival and longevity in the Framingham Heart Study Offspring cohort for which data was available for 1565 subjects
Conclusions: The Gln27Glu and Glu27Glu genotypes and the Glu27 allele were associated with shorter lifespans at young-old ages (cut-off = 72 years) and longer lives in oldest-old ages (e.g., cut-off = 83 years) compared to carriers of the Gln27Gln genotype. The Gln(27)Gln genotype was also associated with age-related diseases, such as cancer.
Indentifier