LongevityMap variant
- Longevity Association
- Significant
- Population
- Chinese
- Study Design
- The distribution of CETP*V and APOE*4 were analyzed in 372 oldest-old women (aged 80-109) and 340 controls (aged 20-58).
- Conclusions
- APOE E4 was less frequent in the oldest-old group.
- HGNC symbol
- UBE4B
- Aliases
- E4; UFD2; HDNB1; UBOX3; UFD2A
- Common name
- ubiquitination factor E4B
- Description
- The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes an additional conjugation factor, E4, which is involved in multiubiquitin chain assembly. This gene is also the strongest candidate in the neuroblastoma tumor suppressor genes. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
- Other longevity studies of this gene
- 3
- OMIM
- 613565
- Ensembl
- ENSG00000130939
- UniProt/Swiss-Prot
- UBE4B_HUMAN
- Entrez Gene
- 10277
- UniGene
- 593974
- HapMap
- View on HapMap
Homologs in model organisms
- Caenorhabditis elegans
- ufd-2
- Danio rerio
- ube4b
- Drosophila melanogaster
- CG9934
- Mus musculus
- Ube4b
- Rattus norvegicus
- Ube4b
- Saccharomyces cerevisiae
- UFD2
- Schizosaccharomyces pombe
- ufd2
- GenAge model organism genes
- A homolog of this gene for Saccharomyces cerevisiae is present as UFD2
Sun et al. (2014)
Other variants which are also part of this study
