LongevityMap Gene

Gene details

HGNC symbol: UBE4B
Aliases: E4; UFD2; HDNB1; UBOX3; UFD2A
Common name: ubiquitination factor E4B
Description: The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes an additional conjugation factor, E4, which is involved in multiubiquitin chain assembly. This gene is also the strongest candidate in the neuroblastoma tumor suppressor genes. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Cytogenetic Location: 1p36.22
UCSC Genome Browser: View 1p36.22 on the UCSC genome browser
OMIM: 613565
Ensembl: ENSG00000130939
UniProt/Swiss-Prot: UBE4B_HUMAN
Entrez Gene: 10277
UniGene: 593974
1000 Genomes: 1000 Genomes

Homologs in model organisms

Caenorhabditis elegans: ufd-2
Danio rerio: ube4b
Drosophila melanogaster: CG9934
Mus musculus: Ube4b
Rattus norvegicus: Ube4b
Saccharomyces cerevisiae: UFD2
Schizosaccharomyces pombe: ufd2

In other databases

GenAge model organism genes

A homolog of this gene for Saccharomyces cerevisiae is present as UFD2

Studies (4)

Significant/Non-significant: 4/0

Study 1

Longevity Association

Population

Study Design

Three most common alleles of the APOE gene were examined in three cohorts (Spanish, Italian and Japanese) to study their association with longevity.

Conclusions

E4 allele was negatively associated with longevity in three cohorts, while the E2 allele was positively associated in Italian and Japanese cohorts.

Indentifier

Reference

Study 2

Longevity Association

Population

Study Design

Three most common alleles of the APOE gene were examined in three cohorts (Spanish, Italian and Japanese) to study their association with longevity.

Conclusions

E4 allele was negatively associated with longevity in three cohorts, while the E2 allele was positively associated in Italian and Japanese cohorts.

Indentifier

Reference

Study 3

Longevity Association

Population

Study Design

Three most common alleles of the APOE gene were examined in three cohorts (Spanish, Italian and Japanese) to study their association with longevity.

Conclusions

E4 allele was negatively associated with longevity in three cohorts, while the E2 allele was positively associated in Italian and Japanese cohorts.

Indentifier

Reference

Study 4

Longevity Association

Population

Study Design

The distribution of CETP*V and APOE*4 were analyzed in 372 oldest-old women (aged 80-109) and 340 controls (aged 20-58).

Conclusions

APOE E4 was less frequent in the oldest-old group.

Indentifier

Reference