LongevityMap variant

Entry Details

Longevity Association
Non-significant
Population
Danish
Study Design
1651 participants in the Danish 1905 cohort study (aged 92-93 years) were genotyped for two SNPs (rs2866164 and Q95H). Furthermore, a group of 575 middle-aged Danish twins (mean age 53.7 years) were tested as a younger control group.
Conclusions
The risk haplotype had no significant survival disadvantage after 6.5 years of follow-up. The distributions of the suggested risk alleles and the resulting haplotypes were not statistically different between the two age cohorts.
Identifier
Q95H
In Other Studies (IDs)
446
Cytogenetic Location
4q23
UCSC Genome Browser
View 4q23 on the UCSC genome browser

Gene details

HGNC symbol
MTTP
Aliases
ABL; MTP 
Common name
microsomal triglyceride transfer protein 
Description
MTP encodes the large subunit of the heterodimeric microsomal triglyceride transfer protein. Protein disulfide isomerase (PDI) completes the heterodimeric microsomal triglyceride transfer protein, which has been shown to play a central role in lipoprotein assembly. Mutations in MTP can cause abetalipoproteinemia. [provided by RefSeq, Jul 2008]
Other longevity studies of this gene
20
OMIM
157147
Ensembl
ENSG00000138823
UniProt/Swiss-Prot
B7Z7X3_HUMAN
Entrez Gene
4547
UniGene
195799
HapMap
View on HapMap

Homologs in model organisms

Danio rerio
mtp
Drosophila melanogaster
Mtp
Mus musculus
Mttp
Rattus norvegicus
Mttp

References

Bathum et al. (2005)

Other variants which are also part of this study