LongevityMap variant

Entry Details

Longevity Association
Non-significant
Population
American (Caucasian)
Study Design
Common polymorphisms in the ADRB2 gene were studied for association with survival and longevity in the Framingham Heart Study Offspring cohort for which data was available for 1565 subjects
Conclusions
No significant associations with longevity were reported for the Arg(16)Gly polymorphism
Identifier
rs1042713
In Other Studies (IDs)
1265
Cytogenetic Location
5q32
UCSC Genome Browser
View 5q32 on the UCSC genome browser

Gene details

HGNC symbol
ADRB2
Aliases
BAR; B2AR; ADRBR; ADRB2R; BETA2AR 
Common name
adrenoceptor beta 2 
Description
This gene encodes beta-2-adrenergic receptor which is a member of the G protein-coupled receptor superfamily. This receptor is directly associated with one of its ultimate effectors, the class C L-type calcium channel Ca(V)1.2. This receptor-channel complex also contains a G protein, an adenylyl cyclase, cAMP-dependent kinase, and the counterbalancing phosphatase, PP2A. The assembly of the signaling complex provides a mechanism that ensures specific and rapid signaling by this G protein-coupled receptor. This gene is intronless. Different polymorphic forms, point mutations, and/or downregulation of this gene are associated with nocturnal asthma, obesity and type 2 diabetes. [provided by RefSeq, Jul 2008]
Other longevity studies of this gene
6
OMIM
109690
Ensembl
ENSG00000169252
UniProt/Swiss-Prot
ADRB2_HUMAN
Entrez Gene
154
UniGene
2551
HapMap
View on HapMap

Homologs in model organisms

Caenorhabditis elegans
ser-3
Caenorhabditis elegans
ser-6
Caenorhabditis elegans
ser-5
Danio rerio
adrb2b
Danio rerio
adrb2a
Drosophila melanogaster
Oamb
Mus musculus
Adrb2
Rattus norvegicus
Adrb2

References

Kulminski et al. (2010)

Other variants which are also part of this study