LongevityMap variant
- Longevity Association
- Significant
- Population
- Russian (Novosibirsk)
- Study Design
- I/D polymorphism was examined in 97 elderly subjects and control group aged 25-64
- Conclusions
- Frequency of D/D genotype among senile and long-living men was significantly lower than in men 55-64 years of age. A similar decrease of this gene frequency was also found in women of the same age.
- HGNC symbol
- ACE
- Aliases
- DCP; ACE1; DCP1; CD143
- Common name
- angiotensin I converting enzyme
- Description
- This gene encodes an enzyme involved in catalyzing the conversion of angiotensin I into a physiologically active peptide angiotensin II. Angiotensin II is a potent vasopressor and aldosterone-stimulating peptide that controls blood pressure and fluid-electrolyte balance. This enzyme plays a key role in the renin-angiotensin system. Many studies have associated the presence or absence of a 287 bp Alu repeat element in this gene with the levels of circulating enzyme or cardiovascular pathophysiologies. Multiple alternatively spliced transcript variants encoding different isoforms have been identified, and two most abundant spliced variants encode the somatic form and the testicular form, respectively, that are equally active. [provided by RefSeq, May 2010]
- Other longevity studies of this gene
- 32
- OMIM
- 106180
- Ensembl
- ENSG00000159640
- UniProt/Swiss-Prot
- ACE_HUMAN
- Entrez Gene
- 1636
- UniGene
- 298469
- HapMap
- View on HapMap
Homologs in model organisms
- Caenorhabditis elegans
- acn-1
- Danio rerio
- ace
- Drosophila melanogaster
- Ance-4
- Drosophila melanogaster
- Ance-3
- Drosophila melanogaster
- Ance-5
- Drosophila melanogaster
- Ance-2
- Drosophila melanogaster
- Acer
- Drosophila melanogaster
- Ance
- Mus musculus
- Ace
- Rattus norvegicus
- Ace
- GenAge model organism genes
- A homolog of this gene for Caenorhabditis elegans is present as acn-1
Shabalin et al. (2003)
Other variants which are also part of this study