LongevityMap variant
- Longevity Association
- Non-significant
- Population
- Italian
- Study Design
- The genotype and allele frequency distribution of I/D polymorphisms were analyzed in 235 Italian patients with sporadic Alzheimer disease, 153 with familial Alzheimer disease, 192 healthy controls and 111 centenarians
- Conclusions
- There were no significant differences in ACE genotypes or allele frequencies in all the studied groups. Centenarians showed the highest allele D frequency, although the value was not statistically significant.
- HGNC symbol
- ACE
- Aliases
- DCP; ACE1; DCP1; CD143
- Common name
- angiotensin I converting enzyme
- Description
- This gene encodes an enzyme involved in catalyzing the conversion of angiotensin I into a physiologically active peptide angiotensin II. Angiotensin II is a potent vasopressor and aldosterone-stimulating peptide that controls blood pressure and fluid-electrolyte balance. This enzyme plays a key role in the renin-angiotensin system. Many studies have associated the presence or absence of a 287 bp Alu repeat element in this gene with the levels of circulating enzyme or cardiovascular pathophysiologies. Multiple alternatively spliced transcript variants encoding different isoforms have been identified, and two most abundant spliced variants encode the somatic form and the testicular form, respectively, that are equally active. [provided by RefSeq, May 2010]
- Other longevity studies of this gene
- 32
- OMIM
- 106180
- Ensembl
- ENSG00000159640
- UniProt/Swiss-Prot
- ACE_HUMAN
- Entrez Gene
- 1636
- UniGene
- 298469
- HapMap
- View on HapMap
Homologs in model organisms
- Caenorhabditis elegans
- acn-1
- Danio rerio
- ace
- Drosophila melanogaster
- Ance-4
- Drosophila melanogaster
- Ance-3
- Drosophila melanogaster
- Ance-5
- Drosophila melanogaster
- Ance-2
- Drosophila melanogaster
- Acer
- Drosophila melanogaster
- Ance
- Mus musculus
- Ace
- Rattus norvegicus
- Ace
- GenAge model organism genes
- A homolog of this gene for Caenorhabditis elegans is present as acn-1
Nacmias et al. (2007)
Other variants which are also part of this study