GenAge entry for Xrcc5 (Mus musculus)
Gene information (ID: 735)
- Symbol
- Xrcc5
- Aliases
- Ku80; Ku86; AI314015
- Name
- X-ray repair complementing defective repair in Chinese hamster cells 5
- Organism
- Mus musculus (AnAge)
- Known functions and activities
- Double strand break-repair protein
Potential relevance to longevity and/or ageing
- Observations
- Deletion results in signs of premature ageing such as osteopenia, atrophic skin, hepatocellular degeneration, and age specific mortality.
- Lifespan Effect
- Decrease
- Genetic Manipulation
- Deletion
- Longevity Category
- Pro-Longevity
- Primary reference
-
- Observations
- Up to ~40% reduced lifespan.
- % change in avg or median lifespan
- Lifespan is about 40% lower.
- Lifespan Effect
- Decrease
- Genetic Manipulation
- Mutations
- Longevity Category
- Pro-Longevity
- Primary reference
-
In other databases
- GenAge human genes
- A homolog of this gene for Homo sapiens is present as XRCC5
- LongevityMap
- A homolog of this gene for Homo sapiens is present as XRCC5
Homologs in other organisms
- Danio rerio
- xrcc5
- Drosophila melanogaster
- Ku80
- Homo sapiens
- XRCC5
- Rattus norvegicus
- Xrcc5
- Schizosaccharomyces pombe
- pku80
External links
- Mouse Genome Informatics
- Search
- Ensembl
- Search
- Entrez Gene
- View on Entrez Gene database (22596)
- Homologues
- Search HomoloGene
- UniProt
- Search
- Internet
- Search Google or Search Google Scholar