- Symbol
- hel-1
- Name
- Spliceosome RNA helicase DDX39B homolog
- Organism
- Caenorhabditis elegans (AnAge)
- Observations
- Hel-1 downregulation resulted in a 9.3% decrease in lifespan compared to wild type worms. This effect was even more pronounced in daf-2 mutants which showed a 26.9% decrease in lifespan. The results suggested that hel-1 promotes longevity by activating DAF-16/FOXO signalling.
- % change in avg or median lifespan
- Mean lifespan is 9% lower.
- Lifespan Effect
- Decrease
- Genetic Manipulation
- RNA interference
- Longevity Category
- Pro-Longevity
- Primary reference
-
- CellAge gene expression
- A homolog of this gene for Homo sapiens is present as DDX39A
- Danio rerio
- ddx39ab
- Danio rerio
- ddx39b
- Danio rerio
- ddx39aa
- Drosophila melanogaster
- Hel25E
- Homo sapiens
- DDX39B
- Homo sapiens
- DDX39A
- Mus musculus
- Ddx39b
- Mus musculus
- Ddx39
- Rattus norvegicus
- Ddx39a
- Rattus norvegicus
- Ddx39b
- Saccharomyces cerevisiae
- SUB2
- Schizosaccharomyces pombe
- uap56
- WormBase
- Search
- Ensembl
- Search
- Entrez Gene
- View on Entrez Gene database (174333)
- Homologues
- Search HomoloGene
- UniProt
- Search
- Internet
- Search Google or Search Google Scholar
GenAge entry for hel-1 (Caenorhabditis elegans)