- Symbol
- sesn-1
- Name
- Sestrin homolog
- Organism
- Caenorhabditis elegans (AnAge)
- Observations
- Mutant SESN-1 worms (ok3157 or tm2827) show a decrease in lifespan at both 20C and 25C (up to 46%). Similarly, RNAi of SESN-1 also decreases lifespan (up to 31%).
- % change in avg or median lifespan
- Median lifespan is up to 46% lower.
- Lifespan Effect
- Decrease
- Genetic Manipulation
- Mutation
- Longevity Category
- Pro-Longevity
- Primary reference
-
- Observations
- Overexpressing SESN-1 results in an increase lifespan compared to wild-types (by up to 16%). Additionally, expression of the SESN-1 gene can also rescue the phenotype of short-lived SESN-1 mutants.
- % change in avg or median lifespan
- Median lifespan is up to 16% higher.
- Lifespan Effect
- Increase
- Genetic Manipulation
- Overexpression
- Longevity Category
- Pro-Longevity
- Primary reference
-
- CellAge gene expression
- A homolog of this gene for Homo sapiens is present as SESN1
- Danio rerio
- si:zfos-80g12.1
- Danio rerio
- sesn2
- Danio rerio
- sesn1
- Danio rerio
- sesn3
- Drosophila melanogaster
- Sesn
- Homo sapiens
- SESN2
- Homo sapiens
- SESN1
- Homo sapiens
- SESN3
- Mus musculus
- Sesn2
- Mus musculus
- Sesn3
- Mus musculus
- Sesn1
- Rattus norvegicus
- Sesn2
- Rattus norvegicus
- Sesn1
- Rattus norvegicus
- Sesn3
- WormBase
- Search
- Ensembl
- Search
- Entrez Gene
- View on Entrez Gene database (171593)
- Homologues
- Search HomoloGene
- UniProt
- Search
- Internet
- Search Google or Search Google Scholar
GenAge entry for sesn-1 (Caenorhabditis elegans)