- Symbol
- Ercc1
- Name
- excision repair cross-complementing rodent repair deficiency, complementation group 1
- Organism
- Mus musculus (AnAge)
- Observations
- Mutations in the ERCC1 (resulting in a complete knock out or a truncated protein), result in a greatly reduced lifespan (less severe for the truncation) and severe signs of premature ageing: runting, abnormalities of liver nuclei, absence of subcutaneous fat, early onset of ferritin deposition in the spleen, kidney malfunction, gross abnormalities of ploidy and cytoplasmic invaginations in nuclei of liver and kidney, and compromised NER and cross-link repair. Additionally, ERCC1-mutant cells undergo premature replicative senescence.
- Lifespan Effect
- Decrease
- Genetic Manipulation
- Mutation
- Longevity Category
- Pro-Longevity
- Primary reference
-
- Observations
- Hypomorphic ERCC1 mice (hemizygous for a single truncated Ercc1 allele, encoding protein lacking seven amino acids) have a decreased median and maximum lifespan, and display symptoms of premature aging, including decline in weight of both whole body and various organs, numerous histopathological lesions, and immune parameters.
- % change in max lifespan
- Maximum lifespan is 83% lower in males and 80% lower in females.
- % change in avg or median lifespan
- Median lifespan is 83% lower in males and 82% lower in females.
- Lifespan Effect
- Decrease
- Genetic Manipulation
- Mutation
- Longevity Category
- Pro-Longevity
- Primary reference
-
- GenAge model organism genes
- A homolog of this gene for Saccharomyces cerevisiae is present as RAD10
- GenAge human genes
- A homolog of this gene for Homo sapiens is present as ERCC1
- LongevityMap
- A homolog of this gene for Homo sapiens is present as ERCC1
- CellAge
- A homolog of this gene for Homo sapiens is present as ERCC1
- Caenorhabditis elegans
- ercc-1
- Danio rerio
- ercc1
- Drosophila melanogaster
- Ercc1
- Homo sapiens
- ERCC1
- Rattus norvegicus
- Ercc1
- Saccharomyces cerevisiae
- RAD10
- Schizosaccharomyces pombe
- swi10
- Mouse Genome Informatics
- Search
- Ensembl
- Search
- Entrez Gene
- View on Entrez Gene database (13870)
- Homologues
- Search HomoloGene
- UniProt
- Search
- Internet
- Search Google or Search Google Scholar