Drosophila melanogasterGenAge entry for DJ-1alpha (Drosophila melanogaster)

Gene information (ID: 178)

Symbol
DJ-1alpha
Aliases
CG6646; DJ-1; DJ-1a; DJ-1A; Dmel\CG6646
Name
DJ-1alpha
Organism
Drosophila melanogaster (AnAge)
Known functions and activities
Possibly involved in the pathogenesis of Parkinson disease

Potential relevance to longevity and/or ageing

Observations
RNA interference shortened maximum lifespan by 13% and resulted in increased sensitivity to oxidative stress and motor impairments.
% change in max lifespan
Maximal lifespan is 13% lower.
Lifespan Effect
Decrease
Genetic Manipulation
RNA interference
Longevity Category
Pro-Longevity
Primary reference

    In other databases

    LongevityMap
    • A homolog of this gene for Homo sapiens is present as PARK7

    Homologs in other organisms

    Caenorhabditis elegans
    djr-1.1
    Caenorhabditis elegans
    djr-1.2
    Danio rerio
    park7
    Homo sapiens
    PARK7
    Mus musculus
    Park7
    Rattus norvegicus
    Park7
    Schizosaccharomyces pombe
    SPAC22E12.03c

    External links

    FlyBase
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    Ensembl
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    Entrez Gene
    View on Entrez Gene database (36543)
    Homologues
    Search HomoloGene
    UniProt
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    Internet
    Search Google or Search Google Scholar