GenAge entry for Prkar2b (Mus musculus)
Gene information (ID: 1738)
- Symbol
- Prkar2b
- Aliases
- Pkarb2; AI451071; AW061005; RII(beta); PKARIIbeta
- Name
- protein kinase, cAMP dependent regulatory, type II beta
- Organism
- Mus musculus (AnAge)
Potential relevance to longevity and/or ageing
- Observations
- Both the median and maximum lifespan (defined as 80% mortality) were significantly increased in knockout males compared to WT littermates. Mutant mice maintained their lean phenotype into old age and showed modestly lower blood glucose. Male mutants were also resistant to age-induced fatty liver, had a decrease in tumor incidence, severity of renal lesions, and age-related cardiac pathology.
- % change in avg or median lifespan
- Median male lifespan is 14% higher.
- Lifespan Effect
- Increase
- Genetic Manipulation
- Knockout
- Longevity Category
- Anti-Longevity
- Primary reference
-
In other databases
- GenAge model organism genes
- A homolog of this gene for Saccharomyces cerevisiae is present as BCY1
- CellAge gene expression
- A homolog of this gene for Homo sapiens is present as PRKAR2B
Homologs in other organisms
- Danio rerio
- PRKAR2B
- Drosophila melanogaster
- Pka-R2
- Homo sapiens
- PRKAR2B
- Rattus norvegicus
- Prkar2b
- Saccharomyces cerevisiae
- BCY1
External links
- Mouse Genome Informatics
- Search
- Ensembl
- Search
- Entrez Gene
- View on Entrez Gene database (19088)
- Homologues
- Search HomoloGene
- UniProt
- Search
- Internet
- Search Google or Search Google Scholar