Cell Senescence Entries for RBP2
- Cell Types
- Cervical cancer, Gastric cancer
- Cell Lines
- AGS, BGC-823, HeLa, HGC-27, KATO-III, SiHa
- Cancer Cell?
- Yes
- Method
- Knockout
- Type of senescence
- Replicative
- Senescence Effect
- Inhibits
- Observations
- In gastric and cervical cancer cells, RBP2-depletion induced cellular senescence, including growth arrest, diminished foci numbers and elevated expression of cyclin-dependent kinase inhibitors p21, p27 and p16.
- Primary Reference
RBP2 Gene Information
- HGNC symbol
- RBP2
- Aliases
- CRBP2; RBPC2; CRBPII; CRABP-II
- Common name
- retinol binding protein 2
- Entrez Id
- 5948
- Description
- This gene encodes an abundant protein present in the small intestinal epithelium. It is thought to participate in the uptake and/or intracellular metabolism of vitamin A. Vitamin A is a fat-soluble vitamin necessary for growth, reproduction, differentiation of epithelial tissues, and vision. This protein may also modulate the supply of retinoic acid to the nuclei of endometrial cells during the menstrual cycle. [provided by RefSeq, Aug 2015]
RBP2 Ontologies
- Gene Ontology
-
Process: GO:8544; epidermis development
GO:1523; retinoid metabolic process
GO:6810; transport
GO:6776; vitamin A metabolic process
Cellular component: GO:5829; cytosol
Function: GO:16918; retinal binding
GO:5501; retinoid binding
GO:19841; retinol binding
GO:5215; transporter activity
Homologs of RBP2 in Model Organisms
- Caenorhabditis elegans
- lbp-5
- Caenorhabditis elegans
- lbp-7
- Caenorhabditis elegans
- lbp-9
- Caenorhabditis elegans
- lbp-8
- Caenorhabditis elegans
- lbp-6
- Danio rerio
- rbp2a
- Drosophila melanogaster
- fabp
- Mus musculus
- Rbp2
- Rattus norvegicus
- Rbp2
In other databases
- GenAge model organism genes
- A homolog of this gene for Caenorhabditis elegans is present as lbp-6
- A homolog of this gene for Caenorhabditis elegans is present as lbp-7
- A homolog of this gene for Caenorhabditis elegans is present as lbp-9
- A homolog of this gene for Caenorhabditis elegans is present as lbp-8
- A homolog of this gene for Drosophila melanogaster is present as fabp
External links
- OMIM
- 180280
- Ensembl
- ENSG00000114113
- Entrez Gene
- 5948
- UniGene
- 655516
- 1000 Genomes
- 1000 Genomes
- HPRD
- GenAtlas
- RBP2
- GeneCards
- RBP2