Cell Senescence Entries for RBP2

Cell Types
Cervical cancer, Gastric cancer
Cell Lines
AGS, BGC-823, HeLa, HGC-27, KATO-III, SiHa
Cancer Cell?
Yes
Method
Knockout
Type of senescence
Unclear
Senescence Effect
Inhibits
Primary Reference
Zeng et al. (2010) The histone demethylase RBP2 Is overexpressed in gastric cancer and its inhibition triggers senescence of cancer cells. Gastroenterology 138(3)981-92 (PubMed)

RBP2 Gene Information

HGNC symbol
RBP2 
Aliases
CRABP-II; CRBP2; CRBPII; RBPC2 
Common name
retinol binding protein 2 
Entrez Id
5948
Description
This gene encodes an abundant protein present in the small intestinal epithelium. It is thought to participate in the uptake and/or intracellular metabolism of vitamin A. Vitamin A is a fat-soluble vitamin necessary for growth, reproduction, differentiation of epithelial tissues, and vision. This protein may also modulate the supply of retinoic acid to the nuclei of endometrial cells during the menstrual cycle. [provided by RefSeq, Aug 2015].

RBP2 Ontologies

Gene Ontology
Process: GO:15908; fatty acid transport
GO:8544; epidermis development
GO:6776; vitamin A metabolic process
Cellular component: GO:5737; cytoplasm
GO:5634; nucleus
GO:5829; cytosol
Function: GO:8289; lipid binding
GO:5504; fatty acid binding
GO:16918; retinal binding
GO:19841; retinol binding
GO:5501; retinoid binding
Show all GO terms

Homologs of RBP2 in Model Organisms

Caenorhabditis elegans
lbp-5
Caenorhabditis elegans
lbp-7
Caenorhabditis elegans
lbp-9
Caenorhabditis elegans
lbp-8
Caenorhabditis elegans
lbp-6
Danio rerio
rbp2a
Drosophila melanogaster
fabp
Mus musculus
Rbp2
Rattus norvegicus
Rbp2

In other databases

GenAge model organism genes
  • A homolog of this gene for Caenorhabditis elegans is present as lbp-6
  • A homolog of this gene for Caenorhabditis elegans is present as lbp-7
  • A homolog of this gene for Caenorhabditis elegans is present as lbp-9
  • A homolog of this gene for Caenorhabditis elegans is present as lbp-8
  • A homolog of this gene for Drosophila melanogaster is present as fabp

External links

OMIM
180280
Ensembl
ENSG00000114113
Entrez Gene
5948
UniGene
655516
1000 Genomes
1000 Genomes
HPRD
GenAtlas
RBP2
GeneCards
RBP2