Cell Senescence Entries for PHB2

Cell Types
Human epithelial
Cell Lines
MCF-7
Cancer Cell?
No
Method
Knockdown
Type of senescence
Unclear
Senescence Effect
Inhibits
Primary Reference
Taniguchi et al. (2018) Prohibitin-2 is a novel regulator of p21WAF1/CIP1 induced by depletion of γ-glutamylcyclotransferase. Biochem Biophys Res Commun 496(1)218-224 (PubMed)

PHB2 Gene Information

HGNC symbol
PHB2 
Aliases
Bap37; BCAP37; p22; REA 
Common name
prohibitin 2 
Entrez Id
11331
Description

PHB2 Ontologies

Gene Ontology
Process: GO:6396; RNA processing
GO:43066; negative regulation of apoptotic process
GO:45892; negative regulation of transcription, DNA-templated
GO:7005; mitochondrion organization
GO:50821; protein stabilization
GO:16477; cell migration
GO:423; mitophagy
GO:70374; positive regulation of ERK1 and ERK2 cascade
GO:42113; B cell activation
GO:6606; protein import into nucleus
GO:1901224; positive regulation of NIK/NF-kappaB signaling
And 22 more GO terms
Cellular component: GO:5730; nucleolus
GO:5634; nucleus
GO:5737; cytoplasm
GO:16020; membrane
GO:32991; protein-containing complex
GO:5886; plasma membrane
GO:5739; mitochondrion
GO:5743; mitochondrial inner membrane
GO:5741; mitochondrial outer membrane
GO:71944; cell periphery
GO:9986; cell surface
And 9 more GO terms
Function: GO:42802; identical protein binding
GO:42803; protein homodimerization activity
GO:5515; protein binding
GO:30331; estrogen receptor binding
GO:8022; protein C-terminus binding
GO:47485; protein N-terminus binding
GO:46982; protein heterodimerization activity
GO:46625; sphingolipid binding
GO:33218; amide binding
Show all GO terms

Homologs of PHB2 in Model Organisms

Caenorhabditis elegans
phb-2
Danio rerio
phb2a
Danio rerio
phb2b
Drosophila melanogaster
Phb2
Mus musculus
Phb2
Rattus norvegicus
Phb2
Saccharomyces cerevisiae
PHB2
Schizosaccharomyces pombe
phb2

In other databases

GenAge model organism genes
  • A homolog of this gene for Saccharomyces cerevisiae is present as PHB2
  • A homolog of this gene for Caenorhabditis elegans is present as phb-2
CellAge gene expression
  • This gene is present as PHB2

External links

OMIM
610704
Ensembl
ENSG00000215021
Entrez Gene
11331
UniGene
504620
1000 Genomes
1000 Genomes
HPRD
GenAtlas
PHB2
GeneCards
PHB2