- Symbol
- PHB2
- Name
- Phb2p
- Organism
- Saccharomyces cerevisiae (AnAge)
- Observations
- Deletion results in a reduction in mean and maximum replicative lifespan and a defect in mitochondrial membrane potential.
- Lifespan Effect
- Decrease
- Genetic Manipulation
- Deletion
- Longevity Category
- Necessary for fitness
- Primary reference
-
- Observations
- Replicative lifespan decreased by 30%
- % change in avg or median lifespan
- Replicative lifespan is 30% lower.
- Lifespan Effect
- Decrease
- Genetic Manipulation
- Deletion
- Longevity Category
- Pro-Longevity
- Primary reference
-
- Observations
- Two classes of prohibitin dependent mutation (pbd1 and pbd2) were isolated and characterised. The effect of these mutations on replicative lifespan was determined, demonstrating that the pbd1 mutant slightly extended lifespan by 11%, whereas in contrast, the pbd2 mutation resulted in a shortening in both the mean- and the maximum-lifespan by (28 and 17%, respectively). The pbd1 mutation was also found to reduce chronological lifespan. Reducing the expression of the PHB2 gene in the pbd mutants was found to retard the rate of growth and to affect replicative lifespan. As the two mutants behave in a different manner they probably affect different aspects of prohibitin function.
- Lifespan Effect
- Not Recorded
- Genetic Manipulation
- Mutation
- Primary reference
-
- GenAge model organism genes
- A homolog of this gene for Caenorhabditis elegans is present as phb-2
- CellAge
- A homolog of this gene for Homo sapiens is present as PHB2
- CellAge gene expression
- A homolog of this gene for Homo sapiens is present as PHB2
- Caenorhabditis elegans
- phb-2
- Danio rerio
- phb2a
- Danio rerio
- phb2b
- Drosophila melanogaster
- Phb2
- Homo sapiens
- PHB2
- Mus musculus
- Phb2
- Rattus norvegicus
- Phb2
- Schizosaccharomyces pombe
- phb2
- Saccharomyces Genome Database
- Search
- Ensembl
- Search
- Entrez Gene
- View on Entrez Gene database (853146)
- Homologues
- Search HomoloGene
- UniProt
- Search
- Internet
- Search Google or Search Google Scholar