Cell Senescence Entries for PARP1
- Cell Types
- Colon cancer, Embryonic kidney
- Cell Lines
- HCT116, HEK293T
- Cancer Cell?
- Yes
- Method
- Knockout
- Type of senescence
- Unclear
- Senescence Effect
- Inhibits
- Primary Reference
- Ghosh et al. (2018) PARP1 depletion induces RIG-I-dependent signaling in human cancer cells. PLoS One 13(3)e0194611 (PubMed)
PARP1 Gene Information
- HGNC symbol
- PARP1
- Aliases
- ADPRT; ARTD1; PARP; PPOL
- Common name
- poly(ADP-ribose) polymerase 1
- Entrez Id
- 142
- Description
- This gene encodes a chromatin-associated enzyme, poly(ADP-ribosyl)transferase, which modifies various nuclear proteins by poly(ADP-ribosyl)ation. The modification is dependent on DNA and is involved in the regulation of various important cellular processes such as differentiation, proliferation, and tumor transformation and also in the regulation of the molecular events involved in the recovery of cell from DNA damage. In addition, this enzyme may be the site of mutation in Fanconi anemia, and may participate in the pathophysiology of type I diabetes. [provided by RefSeq, Jul 2008].
PARP1 Ontologies
- Gene Ontology
-
Process: GO:6915; apoptotic process
GO:6281; DNA repair
GO:6974; cellular response to DNA damage stimulus
GO:6471; protein ADP-ribosylation
GO:6302; double-strand break repair
GO:7179; transforming growth factor beta receptor signaling pathway
GO:10332; response to gamma radiation
GO:10613; positive regulation of cardiac muscle hypertrophy
GO:10990; regulation of SMAD protein complex assembly
GO:16540; protein autoprocessing
GO:23019; signal transduction involved in regulation of gene expression
And 38 more GO terms Cellular component: GO:781; chromosome, telomeric region
GO:5634; nucleus
GO:16020; membrane
GO:5654; nucleoplasm
GO:5730; nucleolus
GO:5635; nuclear envelope
GO:5694; chromosome
GO:16604; nuclear body
GO:43229; intracellular organelle
GO:5737; cytoplasm
GO:35861; site of double-strand break
And 6 more GO terms Function: GO:5515; protein binding
GO:3723; RNA binding
GO:8270; zinc ion binding
GO:46872; metal ion binding
GO:16740; transferase activity
GO:3677; DNA binding
GO:16757; glycosyltransferase activity
GO:51287; NAD binding
GO:3950; NAD+ ADP-ribosyltransferase activity
GO:19899; enzyme binding
GO:30331; estrogen receptor binding
And 10 more GO terms
Homologs of PARP1 in Model Organisms
- Caenorhabditis elegans
- parp-1
- Danio rerio
- parp1
- Drosophila melanogaster
- Parp
- Mus musculus
- Parp1
- Rattus norvegicus
- Parp1
In other databases
- GenAge model organism genes
- GenAge human genes
- This gene is present as PARP1
- LongevityMap
- This gene is present as PARP1
- CellAge gene expression
- This gene is present as PARP1
External links
- OMIM
- 173870
- Ensembl
- ENSG00000143799
- Entrez Gene
- 142
- UniGene
- 177766
- 1000 Genomes
- 1000 Genomes
- HPRD
- GenAtlas
- PARP1
- GeneCards
- PARP1