- Symbol
- Parp1
- Aliases
- PARP; PPOL; ARTD1; Adprp; Adprt1; C80510; parp-1; sPARP-1
- Name
- ADP-ribosyltransferase (NAD+; poly (ADP-ribose) polymerase)
- Organism
- Mus musculus (AnAge)
- Observations
- hPARP-1 transgenic mice exhibit impaired survival rates accompanied by reduced hair growth and premature development of several inflammation and age-associated pathologies, such as adiposity, kyphosis, nephropathy, dermatitis, pneumonitis, cardiomyopathy, hepatitis, and anemia. Mutant male mice showed impaired glucose tolerance, however without developing manifest diabetes. 25% reduction in mean lifespan was observed. No difference in maximal lifespan compared to wt was observed.
- % change in avg or median lifespan
- Average lifespan is 25% lower.
- Lifespan Effect
- Decrease
- Genetic Manipulation
- Ectopic integration
- Longevity Category
- Not Recorded
- Primary reference
-
- GenAge model organism genes
- A homolog of this gene for Caenorhabditis elegans is present as pme-1
- GenAge human genes
- A homolog of this gene for Homo sapiens is present as PARP1
- LongevityMap
- A homolog of this gene for Homo sapiens is present as PARP1
- CellAge
- A homolog of this gene for Homo sapiens is present as PARP1
- CellAge gene expression
- A homolog of this gene for Homo sapiens is present as PARP1
- Caenorhabditis elegans
- parp-1
- Danio rerio
- parp1
- Drosophila melanogaster
- Parp
- Homo sapiens
- PARP1
- Rattus norvegicus
- Parp1
- Mouse Genome Informatics
- Search
- Ensembl
- Search
- Entrez Gene
- View on Entrez Gene database (11545)
- Homologues
- Search HomoloGene
- UniProt
- Search
- Internet
- Search Google or Search Google Scholar
GenAge entry for Parp1 (Mus musculus)