Cell Senescence Entries for MAP3K6

Cell Types
Embryonic kidney, Lung fibroblast
Cell Lines
HEK293T, IMR-90, MRC-5
Cancer Cell?
No
Method
Overexpression
Type of senescence
Replicative
Senescence Effect
Induces
Observations
A library of 200 constitutively activated kinases was screened in order to identify kinases whose constitutive expression decreased cell proliferation and induced expression of senescence markers; p16 and SASP components. A total of 33 kinases showed pro-senescence effects (particularly MAP3K7, PRKCD, and MATK); kinases with strong pro-senescence effects, induced expression of SASP-component genes (e.g. IL1A, IL1B, IL6 and IL8) through activation of an NF-kappaB-dependent transcriptional program. Inhibition of the NF-kappaB, p53, or Rb pathway proved insufficient to prevent kinase-triggered cell cycle arrest.
Primary Reference

    MAP3K6 Gene Information

    HGNC symbol
    MAP3K6 
    Aliases
    ASK2; MEKK6; MAPKKK6 
    Common name
    mitogen-activated protein kinase kinase kinase 6 
    Entrez Id
    9064
    Description
    This gene encodes a serine/threonine protein kinase that forms a component of protein kinase-mediated signal transduction cascades. The encoded kinase participates in the regulation of vascular endothelial growth factor (VEGF) expression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]

    MAP3K6 Ontologies

    Gene Ontology
    Process: GO:7257; activation of JUN kinase activity
    GO:186; activation of MAPKK activity
    GO:6468; protein phosphorylation
    GO:7165; signal transduction
    Cellular component: GO:5622; intracellular
    Function: GO:5524; ATP binding
    GO:4709; MAP kinase kinase kinase activity
    GO:287; magnesium ion binding
    Show all GO terms

    Homologs of MAP3K6 in Model Organisms

    Caenorhabditis elegans
    nsy-1
    Danio rerio
    MAP3K6
    Drosophila melanogaster
    Pk92B
    Mus musculus
    Map3k6
    Rattus norvegicus
    Map3k6
    Saccharomyces cerevisiae
    STE11
    Saccharomyces cerevisiae
    BCK1

    In other databases

    GenAge model organism genes
    • A homolog of this gene for Saccharomyces cerevisiae is present as BCK1
    • A homolog of this gene for Saccharomyces cerevisiae is present as STE11
    GenDR gene expression
    • A homolog of this gene for Mus musculus is present as Map3k6
    GenDR gene manipulations
    • A homolog of this gene for Caenorhabditis elegans is present as nsy-1

    External links

    OMIM
    604468
    Ensembl
    ENSG00000142733
    Entrez Gene
    9064
    UniGene
    194694
    1000 Genomes
    1000 Genomes
    HPRD
    GenAtlas
    MAP3K6
    GeneCards
    MAP3K6