Cell Senescence Entries for HSPB1
- Cell Types
- Mammary epithelial
- Cell Lines
- MCF-10A
- Cancer Cell?
- No
- Method
- Knockdown, Overexpression
- Type of senescence
- Stress-induced
- Senescence Effect
- Inhibits
- Primary Reference
- O'Callaghan-Sunol et al. (2008) Hsp27 modulates p53 signaling and suppresses cellular senescence. Cancer Res 67(24)11779-88 (PubMed)
HSPB1 Gene Information
- HGNC symbol
- HSPB1
- Aliases
- CMT2F; Hs.76067; Hsp25; HSP27; HSP28
- Common name
- heat shock protein family B (small) member 1
- Entrez Id
- 3315
- Description
- This gene encodes a member of the small heat shock protein (HSP20) family of proteins. In response to environmental stress, the encoded protein translocates from the cytoplasm to the nucleus and functions as a molecular chaperone that promotes the correct folding of other proteins. This protein plays an important role in the differentiation of a wide variety of cell types. Expression of this gene is correlated with poor clinical outcome in multiple human cancers, and the encoded protein may promote cancer cell proliferation and metastasis, while protecting cancer cells from apoptosis. Mutations in this gene have been identified in human patients with Charcot-Marie-Tooth disease and distal hereditary motor neuropathy. [provided by RefSeq, Aug 2017].
HSPB1 Ontologies
- Gene Ontology
-
Process: GO:43066; negative regulation of apoptotic process
GO:6986; response to unfolded protein
GO:1895; retina homeostasis
GO:9615; response to virus
GO:70527; platelet aggregation
GO:99641; anterograde axonal protein transport
GO:32760; positive regulation of tumor necrosis factor production
GO:45766; positive regulation of angiogenesis
GO:61077; chaperone-mediated protein folding
GO:6469; negative regulation of protein kinase activity
GO:35924; cellular response to vascular endothelial growth factor stimulus
And 12 more GO terms Cellular component: GO:5634; nucleus
GO:5737; cytoplasm
GO:5856; cytoskeleton
GO:5925; focal adhesion
GO:5615; extracellular space
GO:1904115; axon cytoplasm
GO:5819; spindle
GO:5829; cytosol
GO:70062; extracellular exosome
GO:502; proteasome complex
GO:1533; cornified envelope
And 4 more GO terms Function: GO:3723; RNA binding
GO:42802; identical protein binding
GO:42803; protein homodimerization activity
GO:5515; protein binding
GO:44183; protein folding chaperone
GO:19901; protein kinase binding
GO:61629; RNA polymerase II-specific DNA-binding transcription factor binding
GO:43130; ubiquitin binding
GO:5080; protein kinase C binding
GO:8426; protein kinase C inhibitor activity
Homologs of HSPB1 in Model Organisms
- Caenorhabditis elegans
- hsp-12.6
- Caenorhabditis elegans
- hsp-12.1
- Caenorhabditis elegans
- hsp-12.3
- Caenorhabditis elegans
- hsp-12.2
- Danio rerio
- hspb1
- Drosophila melanogaster
- l(2)efl
- Mus musculus
- Hspb1
- Rattus norvegicus
- Hspb1
In other databases
- GenAge model organism genes
- A homolog of this gene for Caenorhabditis elegans is present as hsp-12.6
- GenAge microarray genes
- This gene is present as HSPB1
- GenDR gene manipulations
- A homolog of this gene for Caenorhabditis elegans is present as hsp-12.6
External links
- OMIM
- 602195
- Ensembl
- ENSG00000106211
- Entrez Gene
- 3315
- UniGene
- 520973
- 1000 Genomes
- 1000 Genomes
- HPRD
- GenAtlas
- HSPB1
- GeneCards
- HSPB1