GenDR Dietary Restriction Gene Manipulation: hsp-12.6
Gene Information (Entrez Gene ID: 177778)
- Symbol
- hsp-12.6
- Name
- Heat Shock Protein
- Organism
- Caenorhabditis elegans (AnAge)
- Entrez Gene ID
- 177778
Potential relevance to dietary restriction and ageing
- Observations
-
hsp-12.6 loss-of-function mutation significantly extends lifespan under ad lib and significantly suppresses intermittent fasting-induced increase in lifespan, to a similar extend to that of daf-16 mutation. HSP-12.6 expression is induced by fasting in various tissues, including body wall muscle and neuronal systems. hsp-16.2 is one of downstream targets of DAF-16 in intermittent fasting-induced longevity. The extent of intermittent fasting-induced longevity in daf-16 hsp-12.6 double mutant is similar to that of single hsp-12.6 or daf-16 mutants [2566].
- References
-
In other databases
- GenAge model organism genes
- This gene is present as hsp-12.6
- GenAge microarray genes
- CellAge
- A homolog of this gene for Homo sapiens is present as HSPB1
- CellAge gene expression
- A homolog of this gene for Homo sapiens is present as HSPB8
Homologs
- Danio rerio
- hspb3
- Danio rerio
- hspb15
- Danio rerio
- hspb2
- Danio rerio
- hspb1
- Danio rerio
- hspb8
- Danio rerio
- si:dkey-1k23.3
- Drosophila melanogaster
- l(2)efl
- Homo sapiens
- HSPB1
- Homo sapiens
- HSPB2
- Homo sapiens
- HSPB3
- Homo sapiens
- HSPB8
- Homo sapiens
- HSPB2-C11orf52
- Mus musculus
- Hspb2
- Mus musculus
- Hspb8
- Mus musculus
- Hspb1
- Mus musculus
- Hspb3
- Rattus norvegicus
- Hspb1
- Rattus norvegicus
- Hspb3
- Rattus norvegicus
- Hspb8
- Rattus norvegicus
- Hspb2
External links
- WormBase
- Search
- Ensembl
- Search
- Entrez Gene
- ID 177778
- Homologues
- Search HomoloGene
- UniProt
- Search
- Internet
- Search Google or Search Google Scholar