Cell Senescence Entries for HSF1

Cell Types
Embryonic kidney
Cell Lines
HEK293
Cancer Cell?
No
Method
Knockdown
Type of senescence
Stress-induced
Senescence Effect
Inhibits
Primary Reference
Kim et al. (2012) The heat shock transcription factor Hsf1 is downregulated in DNA damage-associated senescence, contributing to the maintenance of senescence phenotype. Aging Cell 11(4)617-27 (PubMed)

HSF1 Gene Information

HGNC symbol
HSF1 
Aliases
HSTF1 
Common name
heat shock transcription factor 1 
Entrez Id
3297
Description
The product of this gene is a transcription factor that is rapidly induced after temperature stress and binds heat shock promoter elements (HSE). This protein plays a role in the regulation of lifespan. Expression of this gene is repressed by phosphorylation, which promotes binding by heat shock protein 90. [provided by RefSeq, Jul 2017].

HSF1 Ontologies

Gene Ontology
Process: GO:6355; regulation of transcription, DNA-templated
GO:6397; mRNA processing
GO:51028; mRNA transport
GO:6281; DNA repair
GO:6974; cellular response to DNA damage stimulus
GO:45944; positive regulation of transcription by RNA polymerase II
GO:122; negative regulation of transcription by RNA polymerase II
GO:1900034; regulation of cellular response to heat
GO:165; MAPK cascade
GO:8284; positive regulation of cell population proliferation
GO:6357; regulation of transcription by RNA polymerase II
And 51 more GO terms
Cellular component: GO:5634; nucleus
GO:5737; cytoplasm
GO:5654; nucleoplasm
GO:5829; cytosol
GO:5856; cytoskeleton
GO:5694; chromosome
GO:1990904; ribonucleoprotein complex
GO:48471; perinuclear region of cytoplasm
GO:775; chromosome, centromeric region
GO:16605; PML body
GO:5815; microtubule organizing center
And 10 more GO terms
Function: GO:3677; DNA binding
GO:3700; DNA-binding transcription factor activity
GO:43565; sequence-specific DNA binding
GO:42802; identical protein binding
GO:31490; chromatin DNA binding
GO:5515; protein binding
GO:978; RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:981; DNA-binding transcription factor activity, RNA polymerase II-specific
GO:1227; DNA-binding transcription repressor activity, RNA polymerase II-specific
GO:1990837; sequence-specific double-stranded DNA binding
GO:19901; protein kinase binding
And 12 more GO terms
Show all GO terms

Homologs of HSF1 in Model Organisms

Caenorhabditis elegans
hsf-1
Danio rerio
hsf1
Drosophila melanogaster
Hsf
Mus musculus
Hsf1
Rattus norvegicus
Hsf1
Saccharomyces cerevisiae
HSF1
Schizosaccharomyces pombe
hsf1

In other databases

GenAge model organism genes
  • A homolog of this gene for Caenorhabditis elegans is present as hsf-1
GenAge human genes
  • This gene is present as HSF1
GenDR gene manipulations
  • A homolog of this gene for Caenorhabditis elegans is present as hsf-1

External links

OMIM
140580
Ensembl
ENSG00000185122
Entrez Gene
3297
UniGene
530227
1000 Genomes
1000 Genomes
HPRD
GenAtlas
HSF1
GeneCards
HSF1