Cell Senescence Entries for HSF1
- Cell Types
- Embryonic kidney
- Cell Lines
- HEK293
- Cancer Cell?
- No
- Method
- Knockdown
- Type of senescence
- Stress-induced
- Senescence Effect
- Inhibits
- Primary Reference
- Kim et al. (2012) The heat shock transcription factor Hsf1 is downregulated in DNA damage-associated senescence, contributing to the maintenance of senescence phenotype. Aging Cell 11(4)617-27 (PubMed)
HSF1 Gene Information
- HGNC symbol
- HSF1
- Aliases
- HSTF1
- Common name
- heat shock transcription factor 1
- Entrez Id
- 3297
- Description
- The product of this gene is a transcription factor that is rapidly induced after temperature stress and binds heat shock promoter elements (HSE). This protein plays a role in the regulation of lifespan. Expression of this gene is repressed by phosphorylation, which promotes binding by heat shock protein 90. [provided by RefSeq, Jul 2017].
HSF1 Ontologies
- Gene Ontology
-
Process: GO:6355; regulation of transcription, DNA-templated
GO:6397; mRNA processing
GO:51028; mRNA transport
GO:6281; DNA repair
GO:6974; cellular response to DNA damage stimulus
GO:45944; positive regulation of transcription by RNA polymerase II
GO:122; negative regulation of transcription by RNA polymerase II
GO:1900034; regulation of cellular response to heat
GO:165; MAPK cascade
GO:8284; positive regulation of cell population proliferation
GO:6357; regulation of transcription by RNA polymerase II
And 51 more GO terms Cellular component: GO:5634; nucleus
GO:5737; cytoplasm
GO:5654; nucleoplasm
GO:5829; cytosol
GO:5856; cytoskeleton
GO:5694; chromosome
GO:1990904; ribonucleoprotein complex
GO:48471; perinuclear region of cytoplasm
GO:775; chromosome, centromeric region
GO:16605; PML body
GO:5815; microtubule organizing center
And 10 more GO terms
Show all GO termsFunction: GO:3677; DNA binding
GO:3700; DNA-binding transcription factor activity
GO:43565; sequence-specific DNA binding
GO:42802; identical protein binding
GO:31490; chromatin DNA binding
GO:5515; protein binding
GO:978; RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:981; DNA-binding transcription factor activity, RNA polymerase II-specific
GO:1227; DNA-binding transcription repressor activity, RNA polymerase II-specific
GO:1990837; sequence-specific double-stranded DNA binding
GO:19901; protein kinase binding
And 12 more GO terms
Homologs of HSF1 in Model Organisms
- Caenorhabditis elegans
- hsf-1
- Danio rerio
- hsf1
- Drosophila melanogaster
- Hsf
- Mus musculus
- Hsf1
- Rattus norvegicus
- Hsf1
- Saccharomyces cerevisiae
- HSF1
- Schizosaccharomyces pombe
- hsf1
In other databases
- GenAge model organism genes
- A homolog of this gene for Caenorhabditis elegans is present as hsf-1
- GenAge human genes
- This gene is present as HSF1
- GenDR gene manipulations
- A homolog of this gene for Caenorhabditis elegans is present as hsf-1
External links
- OMIM
- 140580
- Ensembl
- ENSG00000185122
- Entrez Gene
- 3297
- UniGene
- 530227
- 1000 Genomes
- 1000 Genomes
- HPRD
- GenAtlas
- HSF1
- GeneCards
- HSF1