Caenorhabditis elegans GenDR Dietary Restriction Gene Manipulation: hsf-1

Gene Information (Entrez Gene ID: 173078)

Symbol
hsf-1
Name
Heat Shock Factor 1
Organism
Caenorhabditis elegans (AnAge)
Entrez Gene ID
173078

Potential relevance to dietary restriction and ageing

Observations

RNA interference of hsf-1 suppresses normal dauer formation and life-extension due to insulin-like signalling [985]. hsf-1 overexpression extends mean, median, and maximum lifespan by 37, 35, and 29% [2588]. hsf-1 RNAi abrogates lifespan extension by daf-2(e1370) mutation, but not eat-2(ad1116). HSF-1, like DAF-16, is required for daf-2 mutations to extend lifespan [626]. A mutant allele of hsf-1 slightly decreases lifespan under ad lib, but cancels out the lifespan extension effect of bacterial dilution DR [2565]. Solid DR extends the lifespan of hsf-1 mutant with a premature stop codon, that eliminates activation domain, and that of wild-type to a similar extent [2568]. In another experiment, hsf-1 RNAi attenuated lifespan extension by bacterial dilution DR, but only partially that of daf-2 mutation. hsf-1 RNAi attenuated protection against oxidative stress by bacterial dilution DR. hsf-1 expression was induced by bacterial dilution DR [2569].

References

    In other databases

    GenAge model organism genes
    • This gene is present as hsf-1
    GenAge human genes
    • A homolog of this gene for Homo sapiens is present as HSF1
    CellAge
    • A homolog of this gene for Homo sapiens is present as HSF1

    Homologs

    Danio rerio
    hsf1
    Danio rerio
    hsf4
    Drosophila melanogaster
    Hsf
    Homo sapiens
    HSF4
    Homo sapiens
    HSF1
    Mus musculus
    Hsf4
    Mus musculus
    Hsf1
    Rattus norvegicus
    Hsf1
    Rattus norvegicus
    Hsf4
    Saccharomyces cerevisiae
    HSF1

    External links

    WormBase
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    Ensembl
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    Entrez Gene
    ID 173078
    Homologues
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    UniProt
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    Internet
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