The MTOR gene and its putative association with human ageing

Cell Types

Foreskin fibroblast

Cell Lines

BJ

Cancer Cell?

No

Method

Knockout

Type of senescence

Stress-induced

Senescence Effect

Inhibits

Primary Reference

Liu et al. (2020) A large-scale CRISPR screen and identification of essential genes in cellular senescence bypass. Aging (Albany NY) 11(12)4011-4031 (PubMed)

HGNC symbol

MTOR

Aliases

FLJ44809; FRAP; FRAP1; FRAP2; RAFT1; RAPT1

Common name

mechanistic target of rapamycin kinase

Entrez Id

2475

Description

The protein encoded by this gene belongs to a family of phosphatidylinositol kinase-related kinases. These kinases mediate cellular responses to stresses such as DNA damage and nutrient deprivation. This kinase is a component of two distinct complexes, mTORC1, which controls protein synthesis, cell growth and proliferation, and mTORC2, which is a regulator of the actin cytoskeleton, and promotes cell survival and cell cycle progression. This protein acts as the target for the cell-cycle arrest and immunosuppressive effects of the FKBP12-rapamycin complex. Inhibitors of mTOR are used in organ transplants as immunosuppressants, and are being evaluated for their therapeutic potential in SARS-CoV-2 infections. Mutations in this gene are associated with Smith-Kingsmore syndrome and somatic focal cortical dysplasia type II. The ANGPTL7 gene is located in an intron of this gene. [provided by RefSeq, Aug 2020].

Gene Ontology

Process:

GO:16310; phosphorylation
GO:80135; regulation of cellular response to stress
GO:6950; response to stress
GO:18105; peptidyl-serine phosphorylation
GO:2000112; regulation of cellular macromolecule biosynthetic process
GO:42221; response to chemical
GO:32270; positive regulation of cellular protein metabolic process
GO:48511; rhythmic process
GO:6468; protein phosphorylation
GO:32956; regulation of actin cytoskeleton organization
GO:10628; positive regulation of gene expression
GO:9267; cellular response to starvation
GO:1558; regulation of cell growth
GO:1901796; regulation of signal transduction by p53 class mediator
GO:45727; positive regulation of translation
GO:42752; regulation of circadian rhythm
GO:7040; lysosome organization
GO:30163; protein catabolic process
GO:71456; cellular response to hypoxia
GO:43066; negative regulation of apoptotic process
GO:32148; activation of protein kinase B activity
GO:10718; positive regulation of epithelial to mesenchymal transition
GO:31669; cellular response to nutrient levels
GO:10507; negative regulation of autophagy
GO:46889; positive regulation of lipid biosynthetic process
GO:34198; cellular response to amino acid starvation
GO:1900034; regulation of cellular response to heat
GO:31929; TOR signaling
GO:45670; regulation of osteoclast differentiation
GO:31667; response to nutrient levels
GO:51549; positive regulation of keratinocyte migration
GO:1901838; positive regulation of transcription of nucleolar large rRNA by RNA polymerase I
GO:30307; positive regulation of cell growth
GO:43276; anoikis
GO:7584; response to nutrient
GO:16242; negative regulation of macroautophagy
GO:46777; protein autophosphorylation
GO:1932; regulation of protein phosphorylation
GO:1934; positive regulation of protein phosphorylation
GO:2296; T-helper 1 cell lineage commitment
GO:3007; heart morphogenesis
GO:3179; heart valve morphogenesis
GO:6112; energy reserve metabolic process
GO:6207; 'de novo' pyrimidine nucleobase biosynthetic process
GO:6954; inflammatory response
GO:7281; germ cell development
GO:8361; regulation of cell size
GO:9408; response to heat
GO:9791; post-embryonic development
GO:10506; regulation of autophagy
GO:10592; positive regulation of lamellipodium assembly
GO:10831; positive regulation of myotube differentiation
GO:16241; regulation of macroautophagy
GO:18107; peptidyl-threonine phosphorylation
GO:19228; neuronal action potential
GO:30030; cell projection organization
GO:30838; positive regulation of actin filament polymerization
GO:31529; ruffle organization
GO:31641; regulation of myelination
GO:32516; positive regulation of phosphoprotein phosphatase activity
GO:32868; response to insulin
GO:35264; multicellular organism growth
GO:38202; TORC1 signaling
GO:43087; regulation of GTPase activity
GO:43200; response to amino acid
GO:45792; negative regulation of cell size
GO:45859; regulation of protein kinase activity
GO:45945; positive regulation of transcription by RNA polymerase III
GO:48266; behavioral response to pain
GO:48714; positive regulation of oligodendrocyte differentiation
GO:48738; cardiac muscle tissue development
GO:50731; positive regulation of peptidyl-tyrosine phosphorylation
GO:50882; voluntary musculoskeletal movement
GO:51496; positive regulation of stress fiber assembly
GO:51647; nucleus localization
GO:51896; regulation of protein kinase B signaling
GO:55006; cardiac cell development
GO:55013; cardiac muscle cell development
GO:60048; cardiac muscle contraction
GO:70885; negative regulation of calcineurin-NFAT signaling cascade
GO:71230; cellular response to amino acid stimulus
GO:71233; cellular response to leucine
GO:90559; regulation of membrane permeability
GO:1903691; positive regulation of wound healing, spreading of epidermal cells
GO:1904059; regulation of locomotor rhythm
GO:1904690; positive regulation of cytoplasmic translational initiation
GO:1990253; cellular response to leucine starvation
GO:6974; cellular response to DNA damage stimulus
GO:7010; cytoskeleton organization
GO:45821; positive regulation of glycolytic process
GO:71470; cellular response to osmotic stress
GO:1905857; positive regulation of pentose-phosphate shunt
GO:44238; primary metabolic process

Cellular component:

GO:31931; TORC1 complex
GO:5634; nucleus
GO:5737; cytoplasm
GO:16020; membrane
GO:5794; Golgi apparatus
GO:31410; cytoplasmic vesicle
GO:5783; endoplasmic reticulum
GO:5789; endoplasmic reticulum membrane
GO:43231; intracellular membrane-bounded organelle
GO:5739; mitochondrion
GO:5765; lysosomal membrane
GO:5741; mitochondrial outer membrane
GO:139; Golgi membrane
GO:12505; endomembrane system
GO:5764; lysosome
GO:16605; PML body
GO:45335; phagocytic vesicle
GO:5654; nucleoplasm
GO:5829; cytosol
GO:31932; TORC2 complex
GO:5635; nuclear envelope
GO:30425; dendrite

Function:

GO:166; nucleotide binding
GO:4674; protein serine/threonine kinase activity
GO:4712; protein serine/threonine/tyrosine kinase activity
GO:5524; ATP binding
GO:16301; kinase activity
GO:16740; transferase activity
GO:106310; protein serine kinase activity
GO:44877; protein-containing complex binding
GO:5515; protein binding
GO:42802; identical protein binding
GO:51219; phosphoprotein binding
GO:1002; RNA polymerase III type 1 promoter sequence-specific DNA binding
GO:1003; RNA polymerase III type 2 promoter sequence-specific DNA binding
GO:1006; RNA polymerase III type 3 promoter sequence-specific DNA binding
GO:1156; TFIIIC-class transcription factor complex binding
GO:4672; protein kinase activity
GO:43022; ribosome binding

Hide GO terms

Danio rerio

mtor

Drosophila melanogaster

Tor

Mus musculus

Mtor

Rattus norvegicus

Mtor

Saccharomyces cerevisiae

TOR1

Schizosaccharomyces pombe