Cell Senescence Entries for WWP1
- Cell Types
- Lung fibroblast
- Cell Lines
- 2BS, WI-38
- Cancer Cell?
- No
- Method
- Knockdown, Overexpression
- Type of senescence
- Replicative
- Senescence Effect
- Inhibits
- Primary Reference
- Cao et al. (2011) WW domain-containing E3 ubiquitin protein ligase 1 (WWP1) delays cellular senescence by promoting p27(Kip1) degradation in human diploid fibroblasts. J Biol Chem 286(38)33447-56 (PubMed)
WWP1 Gene Information
- HGNC symbol
- WWP1
- Aliases
- AIP5; DKFZP434D2111
- Common name
- WW domain containing E3 ubiquitin protein ligase 1
- Entrez Id
- 11059
- Description
- WW domain-containing proteins are found in all eukaryotes and play an important role in the regulation of a wide variety of cellular functions such as protein degradation, transcription, and RNA splicing. This gene encodes a protein which contains 4 tandem WW domains and a HECT (homologous to the E6-associated protein carboxyl terminus) domain. The encoded protein belongs to a family of NEDD4-like proteins, which are E3 ubiquitin-ligase molecules and regulate key trafficking decisions, including targeting of proteins to proteosomes or lysosomes. Alternative splicing of this gene generates at least 6 transcript variants; however, the full length nature of these transcripts has not been defined. [provided by RefSeq, Jul 2008].
WWP1 Ontologies
- Gene Ontology
-
Process: GO:16567; protein ubiquitination
GO:45892; negative regulation of transcription, DNA-templated
GO:7165; signal transduction
GO:6511; ubiquitin-dependent protein catabolic process
GO:209; protein polyubiquitination
GO:34220; ion transmembrane transport
GO:43161; proteasome-mediated ubiquitin-dependent protein catabolic process
GO:45732; positive regulation of protein catabolic process
GO:46718; viral entry into host cell
GO:7417; central nervous system development
Cellular component: GO:5634; nucleus
GO:5737; cytoplasm
GO:16020; membrane
GO:5886; plasma membrane
GO:5829; cytosol
GO:70062; extracellular exosome
GO:151; ubiquitin ligase complex
Show all GO termsFunction: GO:16740; transferase activity
GO:4842; ubiquitin-protein transferase activity
GO:5515; protein binding
GO:61630; ubiquitin protein ligase activity
Homologs of WWP1 in Model Organisms
- Caenorhabditis elegans
- wwp-1
- Danio rerio
- wwp1
- Drosophila melanogaster
- Su(dx)
- Mus musculus
- Wwp1
- Rattus norvegicus
- Wwp1
- Saccharomyces cerevisiae
- RSP5
In other databases
- GenAge model organism genes
- A homolog of this gene for Caenorhabditis elegans is present as wwp-1
- GenDR gene manipulations
- A homolog of this gene for Caenorhabditis elegans is present as wwp-1
External links
- OMIM
- 602307
- Ensembl
- ENSG00000123124
- Entrez Gene
- 11059
- UniGene
- 655189
- 1000 Genomes
- 1000 Genomes
- HPRD
- GenAtlas
- WWP1
- GeneCards
- WWP1