Caenorhabditis elegans GenDR Dietary Restriction Gene Manipulation: wwp-1

Gene Information (Entrez Gene ID: 171647)

Symbol
wwp-1
Name
WW domain Protein (E3 ubiquitin ligase) 1
Organism
Caenorhabditis elegans (AnAge)
Entrez Gene ID
171647

Potential relevance to dietary restriction and ageing

Observations

RNA interference of wwp-1 decreases median lifespan by 9% in wild-type animals and 24% in daf-2 mutants [2239]. Loss of wwp-1 function by RNAi or mutation reduces lifespan at 25 degree Celsius, but not 20 degree Celsius. wwp-1 overexpression extends lifespan by up to 20%. Reduced levels of wwp-1 completely suppress the extended longevity of eat-2 mutants. Lifespan of wwp-1 mutants across entire food concentration range by bacterial dilution in liquid culture or on solid plates does not noticeable change. There is no difference in wwp-1 mRNA levels under ad lib and DR [2572].

References

    In other databases

    GenAge model organism genes
    • This gene is present as wwp-1
    CellAge
    • A homolog of this gene for Homo sapiens is present as WWP1

    Homologs

    Danio rerio
    wwp2
    Danio rerio
    wwp1
    Danio rerio
    itchb
    Danio rerio
    itcha
    Drosophila melanogaster
    Su(dx)
    Homo sapiens
    WWP1
    Homo sapiens
    WWP2
    Homo sapiens
    ITCH
    Mus musculus
    Wwp1
    Mus musculus
    Wwp2
    Mus musculus
    Itch
    Rattus norvegicus
    Wwp1
    Rattus norvegicus
    Wwp2
    Rattus norvegicus
    Itch
    Saccharomyces cerevisiae
    RSP5
    Schizosaccharomyces pombe
    pub1

    External links

    WormBase
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    Ensembl
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    Entrez Gene
    ID 171647
    Homologues
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    UniProt
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    Internet
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