LongevityMap variant

Entry Details

Longevity Association: Significant
Population: European
Study Design: Genome-wide linkage scan in 2118 European nonagenarian sibships and younger controls from various European studies followed by genome-wide association study in a subgroup of 1228 unrelated nonagenarian and 1907 geographically matched controls
Conclusions: Only one SNP (rs4420638 in the TOMM40/APOE/APOC1 gene locus) was significantly associated with longevity in the GWAS

HGNC symbol: APOC1
Aliases: Apo-CI; ApoC-I; apo-CIB; apoC-IB
Common name: apolipoprotein C1
Description: This gene encodes a member of the apolipoprotein C1 family. This gene is expressed primarily in the liver, and it is activated when monocytes differentiate into macrophages. The encoded protein plays a central role in high density lipoprotein (HDL) and very low density lipoprotein (VLDL) metabolism. This protein has also been shown to inhibit cholesteryl ester transfer protein in plasma. A pseudogene of this gene is located 4 kb downstream in the same orientation, on the same chromosome. This gene is mapped to chromosome 19, where it resides within a apolipoprotein gene cluster. Alternative splicing and the use of alternative promoters results in multiple transcript variants. [provided by RefSeq, Sep 2016]
Other longevity studies of this gene: 3
OMIM: 107710
Ensembl: ENSG00000130208
UniProt/Swiss-Prot: A0A024R0T8_HUMAN
Entrez Gene: 341
UniGene: 110675
HapMap: View on HapMap

CellAge gene expression

Beekman et al. (2013)