LongevityMap Gene
Gene details
- HGNC symbol
- ZFAT
- Aliases
- AITD3; ZFAT1; ZNF406
- Common name
- zinc finger and AT-hook domain containing
- Description
- This gene encodes a protein that likely binds DNA and functions as a transcriptional regulator involved in apoptosis and cell survival. This gene resides in a susceptibility locus for autoimmune thyroid disease (AITD) on chromosome 8q24. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Nov 2009]
- Cytogenetic Location
- 8q24.22
- UCSC Genome Browser
- View 8q24.22 on the UCSC genome browser
- OMIM
- 610931
- Ensembl
- ENSG00000066827
- UniProt/Swiss-Prot
- B7Z6H1_HUMAN
- Entrez Gene
- 57623
- UniGene
- 446172
- 1000 Genomes
- 1000 Genomes
Homologs in model organisms
Studies (1)
Significant/Non-significant: 0/1
- Longevity Association
- Non-significant
- Population
- German
- Study Design
- Genome-wide association study comparing 664,472 autosomal SNPs in 763 long-lived individuals (mean age: 99.7 years) and 1085 controls (mean age: 60.2 years). Top SNPs from the GWAS were further investigated in an independent German sample comprised of 754 long-lived individuals (mean age: 96.9 years) and 860 controls (mean age: 67.3 years).
- Conclusions
- Thirty-two SNPs previously associated with longevity were not associated with longevity in this study
- Indentifier
- rs1036819
- Reference