LongevityMap Gene

Gene details

HGNC symbol
XRCC3 
Aliases
CMM6 
Common name
X-ray repair cross complementing 3 
Description
This gene encodes a member of the RecA/Rad51-related protein family that participates in homologous recombination to maintain chromosome stability and repair DNA damage. This gene functionally complements Chinese hamster irs1SF, a repair-deficient mutant that exhibits hypersensitivity to a number of different DNA-damaging agents and is chromosomally unstable. A rare microsatellite polymorphism in this gene is associated with cancer in patients of varying radiosensitivity. Alternatively spliced transcript variants encoding the same protein have been identified. [provided by RefSeq, Jul 2008]
Cytogenetic Location
14q32.33
UCSC Genome Browser
View 14q32.33 on the UCSC genome browser
OMIM
600675
Ensembl
ENSG00000126215
UniProt/Swiss-Prot
Q53XC8_HUMAN
Entrez Gene
7517
UniGene
592325
1000 Genomes
1000 Genomes

Homologs in model organisms

Danio rerio
xrcc3
Drosophila melanogaster
spn-B
Mus musculus
Xrcc3
Rattus norvegicus
Xrcc3
Saccharomyces cerevisiae
RAD57
Schizosaccharomyces pombe
rhp57

In other databases

GenAge model organism genes
  • A homolog of this gene for Saccharomyces cerevisiae is present as RAD57

Studies (1)

Significant/Non-significant: 0/1

Longevity Association
Non-significant
Population
English
Study Design
T241M and a [AC]n microsatellite in intron 3 polymorphisms were examined in a cohort of newborns (n=290) and a retired population (average age at sampling 70.02 years; n=430)
Conclusions
No evidence of association with longevity was found
Indentifier
T241M
Reference