LongevityMap Gene
Gene details
- HGNC symbol
- XRCC3
- Aliases
- CMM6
- Common name
- X-ray repair cross complementing 3
- Description
- This gene encodes a member of the RecA/Rad51-related protein family that participates in homologous recombination to maintain chromosome stability and repair DNA damage. This gene functionally complements Chinese hamster irs1SF, a repair-deficient mutant that exhibits hypersensitivity to a number of different DNA-damaging agents and is chromosomally unstable. A rare microsatellite polymorphism in this gene is associated with cancer in patients of varying radiosensitivity. Alternatively spliced transcript variants encoding the same protein have been identified. [provided by RefSeq, Jul 2008]
- Cytogenetic Location
- 14q32.33
- UCSC Genome Browser
- View 14q32.33 on the UCSC genome browser
- OMIM
- 600675
- Ensembl
- ENSG00000126215
- UniProt/Swiss-Prot
- Q53XC8_HUMAN
- Entrez Gene
- 7517
- UniGene
- 592325
- 1000 Genomes
- 1000 Genomes
Homologs in model organisms
- Danio rerio
- xrcc3
- Drosophila melanogaster
- spn-B
- Mus musculus
- Xrcc3
- Rattus norvegicus
- Xrcc3
- Saccharomyces cerevisiae
- RAD57
- Schizosaccharomyces pombe
- rhp57
In other databases
- GenAge model organism genes
- A homolog of this gene for Saccharomyces cerevisiae is present as RAD57
Studies (1)
Significant/Non-significant: 0/1
- Longevity Association
- Non-significant
- Population
- English
- Study Design
- T241M and a [AC]n microsatellite in intron 3 polymorphisms were examined in a cohort of newborns (n=290) and a retired population (average age at sampling 70.02 years; n=430)
- Conclusions
- No evidence of association with longevity was found
- Indentifier
- T241M
- Reference