LongevityMap Gene
Gene details
- HGNC symbol
- XRCC1
- Aliases
- RCC
- Common name
- X-ray repair cross complementing 1
- Description
- The protein encoded by this gene is involved in the efficient repair of DNA single-strand breaks formed by exposure to ionizing radiation and alkylating agents. This protein interacts with DNA ligase III, polymerase beta and poly (ADP-ribose) polymerase to participate in the base excision repair pathway. It may play a role in DNA processing during meiogenesis and recombination in germ cells. A rare microsatellite polymorphism in this gene is associated with cancer in patients of varying radiosensitivity. [provided by RefSeq, Jul 2008]
- Cytogenetic Location
- 19q13.31
- UCSC Genome Browser
- View 19q13.31 on the UCSC genome browser
- OMIM
- 194360
- Ensembl
- ENSG00000073050
- UniProt/Swiss-Prot
- B2RCY5_HUMAN
- Entrez Gene
- 7515
- UniGene
- 98493
- 1000 Genomes
- 1000 Genomes
Homologs in model organisms
No homologs found
Studies (2)
Significant/Non-significant: 0/2
Study 1
- Longevity Association
- Non-significant
- Population
- English
- Study Design
- R194W, R399Q and a [AC]n microsatellite in the 3' UTR polymorphisms were examined in a cohort of newborns (n=290) and a retired population (average age at sampling 70.02 years; n=430)
- Conclusions
- No evidence of association with longevity was found
- Indentifier
- R194W
- Reference
Study 2
- Longevity Association
- Non-significant
- Population
- Danish
- Study Design
- 592 SNPs from 77 genes involved in nine sub-processes were analyzed in 1089 long-lived and 736 middle-aged Danes. Then, a replicated study was carried out in a German cohort.
- Conclusions
- The results did not remain significant after correction. The findings drawn from the Danish cohort were not replicated in German samples.
- Indentifier
- rs25487
- Reference