LongevityMap Gene
Gene details
- HGNC symbol
- XPA
- Aliases
- XP1; XPAC
- Common name
- XPA, DNA damage recognition and repair factor
- Description
- This gene encodes a zinc finger protein involved in DNA excision repair. The encoded protein is part of the NER (nucleotide excision repair) complext which is responsible for repair of UV radiation-induced photoproducts and DNA adducts induced by chemical carcinogens. Mutations in this gene are associated with xeroderma pigmentosum complementation group A. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Mar 2009]
- Cytogenetic Location
- 9q22.33
- UCSC Genome Browser
- View 9q22.33 on the UCSC genome browser
- OMIM
- 611153
- Ensembl
- ENSG00000136936
- UniProt/Swiss-Prot
- XPA_HUMAN
- Entrez Gene
- 7507
- UniGene
- 654364
- 1000 Genomes
- 1000 Genomes
Homologs in model organisms
- Caenorhabditis elegans
- xpa-1
- Danio rerio
- xpa
- Drosophila melanogaster
- Xpac
- Mus musculus
- Xpa
- Rattus norvegicus
- Xpa
- Saccharomyces cerevisiae
- RAD14
- Schizosaccharomyces pombe
- rhp14
In other databases
- GenAge model organism genes
- A homolog of this gene for Mus musculus is present as Xpa
- GenAge human genes
- This gene is present as XPA
Studies (1)
Significant/Non-significant: 0/1
- Longevity Association
- Non-significant
- Population
- Danish
- Study Design
- 592 SNPs from 77 genes involved in nine sub-processes were analyzed in 1089 long-lived and 736 middle-aged Danes. Then, a replicated study was carried out in a German cohort.
- Conclusions
- The results did not remain significant after correction. The findings drawn from the Danish cohort were not replicated in German samples.
- Indentifier
- rs2808667
- Reference