LongevityMap Gene

Gene details

HGNC symbol: ULK1
Aliases: ATG1; ATG1A; UNC51; hATG1; Unc51.1
Common name: unc-51 like autophagy activating kinase 1
Description
Cytogenetic Location: 12q24.33
UCSC Genome Browser: View 12q24.33 on the UCSC genome browser
OMIM: 603168
Ensembl: ENSG00000177169
UniProt/Swiss-Prot: ULK1_HUMAN
Entrez Gene: 8408
UniGene: 47061
1000 Genomes: 1000 Genomes

Homologs in model organisms

Caenorhabditis elegans: unc-51
Danio rerio: ulk1b
Danio rerio: ulk1a
Drosophila melanogaster: Atg1
Mus musculus: Ulk1
Rattus norvegicus: Ulk1
Saccharomyces cerevisiae: ATG1

In other databases

GenAge model organism genes

A homolog of this gene for Caenorhabditis elegans is present as unc-51
A homolog of this gene for Saccharomyces cerevisiae is present as ATG1
A homolog of this gene for Drosophila melanogaster is present as Atg1

GenDR gene manipulations

A homolog of this gene for Caenorhabditis elegans is present as unc-51
A homolog of this gene for Saccharomyces cerevisiae is present as ATG1

Studies (1)

Significant/Non-significant: 1/0

Longevity Association

Significant

Population

Dutch

Study Design

1,018 SNPs within a 10-kb window around 40 mTOR signalling genes were studied for differences in variation between 417 unrelated nonagenarian participants and 476 younger controls

Conclusions

As a whole, there was a significant association of genetic variation in the mTOR pathway and familial longevity, though no individual gene was significant after correcting for multiple hypothesis testing

Indentifier

ULK1

Reference