LongevityMap Gene
Gene details
- HGNC symbol
- TUSC3
- Aliases
- M33; N33; MRT7; MRT22; OST3A; D8S1992
- Common name
- tumor suppressor candidate 3
- Description
- This gene is a candidate tumor suppressor gene. It is located within a homozygously deleted region of a metastatic prostate cancer. The gene is expressed in most nonlymphoid human tissues including prostate, lung, liver, and colon. Expression was also detected in many epithelial tumor cell lines. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]
- Cytogenetic Location
- 8p22
- UCSC Genome Browser
- View 8p22 on the UCSC genome browser
- OMIM
- 601385
- Ensembl
- ENSG00000104723
- UniProt/Swiss-Prot
- TUSC3_HUMAN
- Entrez Gene
- 7991
- UniGene
- 426324
- 1000 Genomes
- 1000 Genomes
Homologs in model organisms
- Caenorhabditis elegans
- ZK686.3
- Danio rerio
- tusc3
- Drosophila melanogaster
- Ostgamma
- Mus musculus
- Tusc3
- Rattus norvegicus
- Tusc3
- Saccharomyces cerevisiae
- OST3
In other databases
- GenAge model organism genes
- A homolog of this gene for Saccharomyces cerevisiae is present as OST3
Studies (1)
Significant/Non-significant: 1/0
- Longevity Association
- Significant
- Population
- American (Caucasian)
- Study Design
- Genome-wide association study in 801 centenarians and 914 healthy controls
- Conclusions
- 281 SNPs were found to discriminate between cases and controls
- Indentifier
- rs882696
- Reference