LongevityMap Gene
Gene details
- HGNC symbol
- TNFSF11
- Aliases
- ODF; OPGL; sOdf; CD254; OPTB2; RANKL; TNLG6B; TRANCE; hRANKL2
- Common name
- TNF superfamily member 11
- Description
- This gene encodes a member of the tumor necrosis factor (TNF) cytokine family which is a ligand for osteoprotegerin and functions as a key factor for osteoclast differentiation and activation. This protein was shown to be a dentritic cell survival factor and is involved in the regulation of T cell-dependent immune response. T cell activation was reported to induce expression of this gene and lead to an increase of osteoclastogenesis and bone loss. This protein was shown to activate antiapoptotic kinase AKT/PKB through a signaling complex involving SRC kinase and tumor necrosis factor receptor-associated factor (TRAF) 6, which indicated this protein may have a role in the regulation of cell apoptosis. Targeted disruption of the related gene in mice led to severe osteopetrosis and a lack of osteoclasts. The deficient mice exhibited defects in early differentiation of T and B lymphocytes, and failed to form lobulo-alveolar mammary structures during pregnancy. Two alternatively spliced transcript variants have been found. [provided by RefSeq, Jul 2008]
- Cytogenetic Location
- 13q14.11
- UCSC Genome Browser
- View 13q14.11 on the UCSC genome browser
- OMIM
- 602642
- Ensembl
- ENSG00000120659
- UniProt/Swiss-Prot
- Q54A98_HUMAN
- Entrez Gene
- 8600
- UniGene
- 333791
- 1000 Genomes
- 1000 Genomes
Homologs in model organisms
- Danio rerio
- tnfsf11
- Mus musculus
- Tnfsf11
- Rattus norvegicus
- LOC103689974
- Rattus norvegicus
- Tnfsf11
Studies (1)
Significant/Non-significant: 0/1
- Longevity Association
- Non-significant
- Population
- Korean
- Study Design
- 463 biomarkers in 176 disease associated genes were examined in 137 long lived individuals (>90 y, 59.1% female, 96.73 ± 3.97 y) and 213 young controls (12-14 y, 39.4% female, 12.93 ± 0.80)
- Conclusions
- Associations between several genes and longevity were detected at a P-value less than 0.01, though most were not significant after correcting for multiple hypothesis testing
- Indentifier
- rs1054016
- Reference