LongevityMap Gene
Gene details
- HGNC symbol
- TLR4
- Aliases
- TOLL; CD284; TLR-4; ARMD10
- Common name
- toll like receptor 4
- Description
- The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This receptor has been implicated in signal transduction events induced by lipopolysaccharide (LPS) found in most gram-negative bacteria. Mutations in this gene have been associated with differences in LPS responsiveness. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]
- Cytogenetic Location
- 9q33.1
- UCSC Genome Browser
- View 9q33.1 on the UCSC genome browser
- OMIM
- 603030
- Ensembl
- ENSG00000136869
- UniProt/Swiss-Prot
- TLR4_HUMAN
- Entrez Gene
- 7099
- UniGene
- 174312
- 1000 Genomes
- 1000 Genomes
Homologs in model organisms
- Danio rerio
- tlr4ba
- Danio rerio
- tlr4bb
- Danio rerio
- tlr4al
- Drosophila melanogaster
- Tl
- Drosophila melanogaster
- MstProx
- Drosophila melanogaster
- Toll-4
- Drosophila melanogaster
- Tehao
- Mus musculus
- Tlr4
- Rattus norvegicus
- Tlr4
In other databases
- CellAge
- This gene is present as TLR4
Studies (2)
Significant/Non-significant: 1/1
Study 1
- Longevity Association
- Significant
- Population
- Italian
- Study Design
- ASP299GLY polymorphism was examined in 105 young Sicilian men (mean age, 41 years; range, 20-46 years) with acute myocardial infarction, 127 men matched by age strata (mean age, 38 years; range, 20-50 years) and 55 Sicilian oldest old men (mean age, 100 years; range, 96-104 years)
- Conclusions
- ASP299GLY polymorphism shows a significantly lower frequency in patients affected by myocardial infarction compared to controls, whereas centenarians show a higher frequency
- Indentifier
- Asp299Gly
- Reference
Study 2
- Longevity Association
- Non-significant
- Population
- German
- Study Design
- The functional polymorphism Asp299Gly in the TLR4 gene was studied in 273 long-lived men (95-107 years), 606 male early-onset myocardial infarction patients and 594 appropriate controls from Germany
- Conclusions
- No noteworthy influence of the TLR4 polymorphism upon human longevity was found
- Indentifier
- Asp299Gly
- Reference