LongevityMap Gene
Gene details
- HGNC symbol
- SYBU
- Aliases
- OCSYN; SNPHL; GOLSYN
- Common name
- syntabulin
- Description
- Syntabulin/GOLSYN is part of a kinesin motor-adaptor complex that is critical for the anterograde axonal transport of active zone components and contributes to activity-dependent presynaptic assembly during neuronal development (Cai et al., 2007 [PubMed 17611281]).[supplied by OMIM, Mar 2008]
- Cytogenetic Location
- 8q23.2
- UCSC Genome Browser
- View 8q23.2 on the UCSC genome browser
- OMIM
- 611568
- Ensembl
- ENSG00000147642
- UniProt/Swiss-Prot
- B7Z4D2_HUMAN
- Entrez Gene
- 55638
- UniGene
- 390738
- 1000 Genomes
- 1000 Genomes
Homologs in model organisms
Studies (1)
Significant/Non-significant: 0/1
- Longevity Association
- Non-significant
- Population
- German
- Study Design
- Genome-wide association study comparing 664,472 autosomal SNPs in 763 long-lived individuals (mean age: 99.7 years) and 1085 controls (mean age: 60.2 years). Top SNPs from the GWAS were further investigated in an independent German sample comprised of 754 long-lived individuals (mean age: 96.9 years) and 860 controls (mean age: 67.3 years).
- Conclusions
- Thirty-two SNPs previously associated with longevity were not associated with longevity in this study
- Indentifier
- rs3133926
- Reference