LongevityMap Gene

Gene details

HGNC symbol: SUCLA2
Aliases: A-SCS; A-BETA; MTDPS5; SCS-betaA
Common name: succinate-CoA ligase ADP-forming beta subunit
Description: Succinyl-CoA synthetase (SCS) is a mitochondrial matrix enzyme that acts as a heterodimer, being composed of an invariant alpha subunit and a substrate-specific beta subunit. The protein encoded by this gene is an ATP-specific SCS beta subunit that dimerizes with the SCS alpha subunit to form SCS-A, an essential component of the tricarboxylic acid cycle. SCS-A hydrolyzes ATP to convert succinate to succinyl-CoA. Defects in this gene are a cause of myopathic mitochondrial DNA depletion syndrome. A pseudogene of this gene has been found on chromosome 6. [provided by RefSeq, Jul 2008]
Cytogenetic Location: 13q14.2
UCSC Genome Browser: View 13q14.2 on the UCSC genome browser
OMIM: 603921
Ensembl: ENSG00000136143
UniProt/Swiss-Prot: E5KS60_HUMAN
Entrez Gene: 8803
UniGene: 743361
1000 Genomes: 1000 Genomes

Homologs in model organisms

Caenorhabditis elegans: suca-1
Danio rerio: sucla2
Drosophila melanogaster: skap
Mus musculus: Sucla2
Rattus norvegicus: Sucla2
Saccharomyces cerevisiae: LSC2
Schizosaccharomyces pombe: SPCC1620.08

In other databases

GenAge model organism genes

A homolog of this gene for Saccharomyces cerevisiae is present as LSC2

GenAge microarray genes

This gene is present as SUCLA2

Studies (1)

Significant/Non-significant: 0/1

Longevity Association

Non-significant

Population

European

Study Design

Meta-analysis of genome-wide association studies of survival and survival free of major disease or death. In total, there were 25,007 participants over 55 years of age and followed-up for over 10 years for mortality and over 8 years for event-free survival.

Conclusions

No SNP was significantly associated with time to event after correcting for multiple testing, but 8 independent SNPs predicted event-free survival at a suggestive threshold

Indentifier

rs8001976

Reference