LongevityMap Gene
Gene details
- HGNC symbol
- SLC6A4
- Aliases
- HTT; 5HTT; OCD1; SERT; 5-HTT; SERT1; hSERT; 5-HTTLPR
- Common name
- solute carrier family 6 member 4
- Description
- This gene encodes an integral membrane protein that transports the neurotransmitter serotonin from synaptic spaces into presynaptic neurons. The encoded protein terminates the action of serotonin and recycles it in a sodium-dependent manner. This protein is a target of psychomotor stimulants, such as amphetamines and cocaine, and is a member of the sodium:neurotransmitter symporter family. A repeat length polymorphism in the promoter of this gene has been shown to affect the rate of serotonin uptake and may play a role in sudden infant death syndrome, aggressive behavior in Alzheimer disease patients, and depression-susceptibility in people experiencing emotional trauma. [provided by RefSeq, Jul 2008]
- Cytogenetic Location
- 17q11.2
- UCSC Genome Browser
- View 17q11.2 on the UCSC genome browser
- OMIM
- 182138
- Ensembl
- ENSG00000108576
- UniProt/Swiss-Prot
- B2R7Y7_HUMAN
- Entrez Gene
- 6532
- UniGene
- 29792
- 1000 Genomes
- 1000 Genomes
Homologs in model organisms
- Caenorhabditis elegans
- mod-5
- Danio rerio
- slc6a4a
- Drosophila melanogaster
- SerT
- Mus musculus
- Slc6a4
- Rattus norvegicus
- Slc6a4
In other databases
- GenAge model organism genes
- A homolog of this gene for Caenorhabditis elegans is present as mod-5
Studies (1)
Significant/Non-significant: 1/0
- Longevity Association
- Significant
- Population
- Japanese
- Study Design
- Two alleles, 44-bp insertion (l allele) or deletion (s allele) in the promoter region, were examined in 265 Japanese centenarians and control subjects
- Conclusions
- The frequency of the l/l genotype and the l allele was significantly greater in centenarians than in younger control subjects, particularly in women
- Indentifier
- SLC6A4
- Reference