LongevityMap Gene
Gene details
- HGNC symbol
- SCAF4
- Aliases
- SRA4; SFRS15
- Common name
- SR-related CTD associated factor 4
- Description
- This gene likely encodes a member of the arginine/serine-rich splicing factor family. A similar protein in Rat appears to bind the large subunit of RNA polymerase II and provide a link between transcription and pre-mRNA splicing. Alternatively spliced transcript variants have been described. [provided by RefSeq, Feb 2009]
- Cytogenetic Location
- 21q22.11
- UCSC Genome Browser
- View 21q22.11 on the UCSC genome browser
- OMIM
- 616023
- Ensembl
- ENSG00000156304
- UniProt/Swiss-Prot
- SFR15_HUMAN
- Entrez Gene
- 57466
- UniGene
- 17255
- 1000 Genomes
- 1000 Genomes
Homologs in model organisms
- Caenorhabditis elegans
- nrd-1
- Danio rerio
- scaf4b
- Danio rerio
- scaf4a
- Drosophila melanogaster
- CG4266
- Mus musculus
- Scaf4
- Rattus norvegicus
- Scaf4
Studies (1)
Significant/Non-significant: 0/1
- Longevity Association
- Non-significant
- Population
- Italian (Southern)
- Study Design
- A two-stage case-control study was performed to identify the association between longevity and variation of in homeostasis regulation pathway genes. 317 SNPs in 104 genes were analyzed in 78 cases (≥90 years, median age 98 years, 42 females) and 71 controls (<90 years, median age 67 years, 32 females) in stage 1. Then, 31 candidate SNPs identified in stage 1 (π markers = 0.1) were analyzed in an independent sample composed by 288 cases (≥90 years, median age 92 years, 163 females) and 554 controls (<90 years, median age 67 years, 277 females).
- Conclusions
- After adjustment for multiple testing, no significant association was identified between various SNPs and longevity.
- Indentifier
- rs12626475
- Reference