LongevityMap Gene
Gene details
- HGNC symbol
- RRAGC
- Aliases
- GTR2; RAGC; TIB929
- Common name
- Ras related GTP binding C
- Description
- This gene encodes a member of the GTR/RAG GTP-binding protein family. The encoded protein is a monomeric guanine nucleotide-binding protein which forms a heterodimer with RRAGA and RRAGB and is primarily localized to the cytoplasm. The encoded protein promotes intracellular localization of the mTOR complex. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2012]
- Cytogenetic Location
- 1p34.3
- UCSC Genome Browser
- View 1p34.3 on the UCSC genome browser
- OMIM
- 608267
- Ensembl
- ENSG00000116954
- UniProt/Swiss-Prot
- B4DQ03_HUMAN
- Entrez Gene
- 64121
- UniGene
- 532461
- 1000 Genomes
- 1000 Genomes
Homologs in model organisms
- Caenorhabditis elegans
- ragc-1
- Danio rerio
- rragca
- Danio rerio
- rragcb
- Drosophila melanogaster
- RagC-D
- Mus musculus
- Rragc
- Rattus norvegicus
- Rragc
- Saccharomyces cerevisiae
- GTR2
In other databases
- GenAge model organism genes
- A homolog of this gene for Caenorhabditis elegans is present as ragc-1
- GenAge microarray genes
- This gene is present as RRAGC
Studies (1)
Significant/Non-significant: 1/0
- Longevity Association
- Significant
- Population
- Dutch
- Study Design
- 1,018 SNPs within a 10-kb window around 40 mTOR signalling genes were studied for differences in variation between 417 unrelated nonagenarian participants and 476 younger controls
- Conclusions
- As a whole, there was a significant association of genetic variation in the mTOR pathway and familial longevity, though no individual gene was significant after correcting for multiple hypothesis testing
- Indentifier
- RRAGC
- Reference