LongevityMap Gene

Gene details

HGNC symbol: RPS6KA2
Aliases: RSK; HU-2; RSK3; p90RSK2; p90-RSK3; pp90RSK3; MAPKAPK1C; S6K-alpha; S6K-alpha2
Common name: ribosomal protein S6 kinase A2
Description: This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains two non-identical kinase catalytic domains and phosphorylates various substrates, including members of the mitogen-activated kinase (MAPK) signalling pathway. The activity of this protein has been implicated in controlling cell growth and differentiation. Alternative splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jan 2016]
Cytogenetic Location: 6q27
UCSC Genome Browser: View 6q27 on the UCSC genome browser
OMIM: 601685
Ensembl: ENSG00000071242
UniProt/Swiss-Prot: B7Z3B5_HUMAN
Entrez Gene: 6196
UniGene: 655277
1000 Genomes: 1000 Genomes

Homologs in model organisms

Caenorhabditis elegans: rskn-1
Danio rerio: rps6ka2
Drosophila melanogaster: S6kII
Mus musculus: Rps6ka2
Rattus norvegicus: Rps6ka2
Saccharomyces cerevisiae: TPK3

In other databases

GenAge model organism genes

A homolog of this gene for Saccharomyces cerevisiae is present as TPK3

Studies (1)

Significant/Non-significant: 0/1

Longevity Association

Non-significant

Population

Caucasians

Study Design

Meta-analysis of GWAS in Caucasians from four prospective cohort studies: the Age, Gene/Environment Susceptibility-Reykjavik Study, the Cardiovascular Health Study, the Framingham Heart Study, and the Rotterdam Study participating in the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium. Longevity was defined as survival to age 90 years or older (n = 1,836); the comparison group comprised cohort members who died between the ages of 55 and 80 years (n = 1,955).

Conclusions

There were 273 single-nucleotide polymorphism (SNP) associations with p < .0001, but none reached significance after correcting for multiple testing

Indentifier

rs12198299

Reference