LongevityMap Gene
Gene details
- HGNC symbol
- RPS6KA1
- Aliases
- RSK; HU-1; RSK1; p90Rsk; MAPKAPK1A
- Common name
- ribosomal protein S6 kinase A1
- Description
- This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains 2 nonidentical kinase catalytic domains and phosphorylates various substrates, including members of the mitogen-activated kinase (MAPK) signalling pathway. The activity of this protein has been implicated in controlling cell growth and differentiation. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
- Cytogenetic Location
- 1p36.11
- UCSC Genome Browser
- View 1p36.11 on the UCSC genome browser
- OMIM
- 601684
- Ensembl
- ENSG00000117676
- UniProt/Swiss-Prot
- KS6A1_HUMAN
- Entrez Gene
- 6195
- UniGene
- 149957
- 1000 Genomes
- 1000 Genomes
Homologs in model organisms
- Caenorhabditis elegans
- rskn-1
- Danio rerio
- rps6ka1
- Drosophila melanogaster
- S6kII
- Mus musculus
- Rps6ka1
- Rattus norvegicus
- Rps6ka1
- Saccharomyces cerevisiae
- TPK3
In other databases
- GenAge model organism genes
- A homolog of this gene for Saccharomyces cerevisiae is present as TPK3
- GenAge microarray genes
- This gene is present as RPS6KA1
Studies (1)
Significant/Non-significant: 0/1
- Longevity Association
- Non-significant
- Population
- American of Japanese origin
- Study Design
- 81 tagSNPs that provided virtually complete coverage of key mTOR genes complex genes MTOR, RPTOR, and RICTOR, as well as RPS6KA1, were tested in 814 males (440 aged 95 years and older, 374 controls) for association with longevity and health span phenotypes.
- Conclusions
- No association was found between genotypes and longevity or aging-related biologic, clinical or functional phenoypes after mutiple test correction.
- Indentifier
- rs2278978
- Reference