LongevityMap Gene

Gene details

HGNC symbol: RORB
Aliases: RZRB; NR1F2; ROR-BETA; RZR-BETA; bA133M9.1
Common name: RAR related orphan receptor B
Description: The protein encoded by this gene is a member of the NR1 subfamily of nuclear hormone receptors. It is a DNA-binding protein that can bind as a monomer or as a homodimer to hormone response elements upstream of several genes to enhance the expression of those genes. The encoded protein has been shown to interact with NM23-2, a nucleoside diphosphate kinase involved in organogenesis and differentiation, and to help regulate the expression of some genes involved in circadian rhythm. [provided by RefSeq, Feb 2014]
Cytogenetic Location: 9q21.13
UCSC Genome Browser: View 9q21.13 on the UCSC genome browser
OMIM: 601972
Ensembl: ENSG00000198963
UniProt/Swiss-Prot: Q58EY0_HUMAN
Entrez Gene: 6096
UniGene: 494178
1000 Genomes: 1000 Genomes

Homologs in model organisms

Caenorhabditis elegans: nhr-23
Danio rerio: rorb
Drosophila melanogaster: Hr46
Mus musculus: Rorb
Rattus norvegicus: Rorb

In other databases

GenAge model organism genes

A homolog of this gene for Caenorhabditis elegans is present as nhr-23

Studies (1)

Significant/Non-significant: 0/1

Longevity Association

Non-significant

Population

Caucasians

Study Design

Meta-analysis of GWAS in Caucasians from four prospective cohort studies: the Age, Gene/Environment Susceptibility-Reykjavik Study, the Cardiovascular Health Study, the Framingham Heart Study, and the Rotterdam Study participating in the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium. Longevity was defined as survival to age 90 years or older (n = 1,836); the comparison group comprised cohort members who died between the ages of 55 and 80 years (n = 1,955).

Conclusions

There were 273 single-nucleotide polymorphism (SNP) associations with p < .0001, but none reached significance after correcting for multiple testing

Indentifier

rs4745348

Reference